实验性急性肺损伤血浆内皮素和一氧化氮的变化及作用  

THE CHANGES OF PLASMA ENDOTHELIN AND NITRIC OXIDE ON RESPIRATORY DISTRESS SYNDROME IN DOGS

作　　者：蹇华胜[1] 孙薇[1] 毕敏[1] 

机构地区：[1]第三军医大学西南医院急诊科,重庆630038

出　　处：《急诊医学》1997年第3期132-134,共3页

摘　　要：应用犬油酸型呼吸窘迫综合征模型，放射免疫分析法测定血浆内皮素，氧化还原法测定血浆一氧化氮代谢产物。结果显示，血浆内皮亲于静脉注射油酸后6h显著高于油酸注入前，且显著高于对照组（P＜0．05）。血浆一氧化氮于静脉注射油酸后1、2、4、6h均显著高于油酸注入前和对照组（P＜0．05）。提示，血浆内皮素和一氧化氮增高是呼吸窘迫综合征的一个重要特征，血浆内皮素可能与病情的严重程度有关，血浆一氧化氮增高可能与呼吸窘迫综合征的血压下降有关。The respiratory distress syndrome models were maded in 13 dogs with oleic acid. The plasma levelsof endothelin and NO2 (oxide product of nitric oxide) were measured by radio-immunoassay and oxidation-reduc-tion. The results showed that the Plasma concentration of endothelin increased significantly in the 6st hour afteroleic acid injection (P<0. 05), and the plasma levels of NO2 were higher (P<0. 01~0. 05) in 1, 2, 4, 6 hoursafter oleic acid administration than before and control group. These findings suggest that it is an important featurethat the levels of plasma endothelin and nitric oxide increase on adult respiratory distress syndrome and the concen-tration of plasma endothelin is related to course of the disease, and there can be a relation between nitric oxide andhypotension on the disease.

关 键 词：呼吸窘迫综合征 内皮素 一氧化氮 

分 类 号：R563.8[医药卫生—呼吸系统]