广州市2002-2006年登革热病例特征  

Clinical characteristics of the patients with dengue fever seenh from 2002 to 2006 in Guangzhou

作　　者：应若素[1] 唐小平[1] 张复春[1] 蔡卫平[1] 陈燕清[1] 王建[1] 洪文昕[1] 龙英姿[1] 

机构地区：[1]广州市第八人民医院感染科,510060

出　　处：《中华实验和临床病毒学杂志》2007年第2期123-125,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的分析2002-2006年广州市1342例登革热（dengue fever，DF）患者病例特征，以期更好地做好DF的防治工作。方法对我院2002-2006年收治的1342例DF患者的资料进行回顾性分析，用C6／36细胞分离血液登革病毒（dengue virus，DV），逆转录聚合酶链反应与基因测序法鉴定病毒。结果1342例患者平均年龄为34．4岁，分布无明显性别差异。大多数患者有明显的病毒血症，主要临床表现为发热（100％）、头痛（85．9％）、肌肉酸痛（64．5％）、骨痛（46．6％）和皮疹（65．9％）等。实验室检查外周血白细胞及血小板减少者分别占66．0％和61．3％，丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）升高分别占69．0％和85．7％，部分患者（28．4％）出现血钾降低，除2例诊断为登革出血热外，均诊断为典型登革热。病原学检查血清登革病毒抗体IgM（DF-IgM）阳性率为90％，其中病程5天内累积阳性率为31．3％，8天内为86．4％，经病毒分离与鉴定证实均为DV—Ⅰ型感染。结论广州市2002-2006年流行的DF均为DV—Ⅰ型所致，绝大多数病例符合DF的典型临床表现，肝损害为常见的并发症，登革出血热极少见。Objective To study the clinical characteristics of the patients with dengue fever （DF） seen from 2002 to 2006 in Guangzhou in order to prevent and treat dengue fever better. Methods Clinical data from 1342 inpatients with DF seen from 2002 to 2006 were retrospectively analyzed. The dengue virus was isolated by C6/36 cell culture and genotyped by reverse transcriptase-polymerase chain reaction and gene sequence analysis. Results The average age of the patients was 34.4 years, without sex difference in distribution. Most of the patients had obvious toxemic symptoms including fever （100%）, headache （85.9%）, myalgia （64.5%）, bone soreneas （46,6 % ） and skin rash （65.9 % ）. Leukopenia, thrombocytopenia, elevated alanine aminotransferase, elevated aspartate aminotransferase and hypokalemia were found in 66.0%, 61.3%, 69.0%, 85.7% and 28.4% of patients, respectively. DF-IgM could be detected in 90% of patients. The virus was identified as dengue virus type-Ⅰ. Conclusions The epidemic of DF was caused by dengue virus-Ⅰ from 2002 to 2006 in Guangzhou. Most of the patients had classic DF clinical manifestation with high percentage of hepatic injury. Few patients progreased to dengue hemorrhagic fever.

关 键 词：登革热 登革病毒 临床表现 

分 类 号：R686[医药卫生—骨科学]