轮状病毒G血清型和P基因型与腹泻严重程度的关系  

Relationship between severity of rotavirus diarrhea and serotype G and genotype P

作　　者：张丽杰[1] 方肇寅[1] 曾光[2] Duncan Steele 江保民 Paul Kilgore 

机构地区：[1]中国疾病预防控制中心病毒病预防控制所腹泻室,北京100052 [2]中国疾病预防控制中心 [3]World Health Organization [4]USA Centers for Disease Control and Prevention [5]International Vaccine Institute

出　　处：《中华实验和临床病毒学杂志》2007年第2期144-146,共3页Chinese Journal of Experimental and Clinical Virology

基　　金：美国适宜卫生科技组织基金资助（PATH,GAV.1142-01-07228-LPS）;世界卫生组织基金资助（V27/181/123）

摘　　要：目的了解轮状病毒G血清型和P基因型与腹泻严重程度之间的关系。方法收集2001年8月至2003年7月4个监测点医院5岁以下住院腹泻儿童的粪便标本和临床信息，对标本进行轮状病毒检测和分型，根据Vesikari 20点评分法对轮状病毒腹泻患儿的严重程度进行评分。结果当与P[8]基因型结合时，P[8]G1型和P[8]G3型患儿的严重程度评分分别为13分和12分，腹泻天数分别为6d和5d，G1型患儿中发热的比例高于G3型（97％与73％），而且发热患儿的最高体温G1型也高于G3型（39℃和38．6℃）。当与G3血清型结合时，P[4]G3和P[8]G3型腹泻严重程度评分无统计学差异，但P[4]型比P[8]型的腹泻天数长（分别为6．5d和5d），而P[8]型呕吐的最高次数比P[4]型多（分别为4次和3次）。结论当与P[8]型结合时，G1型腹泻比G3型腹泻严重。当与G3型结合时，P[4]和P[8]型腹泻严重程度评分无差异。Objective To learn the relationship between severity of rotavirus diarrhea and serotype G and genotype P. Method The clinical information and fecal specimens of hospitalized children 〈 5 years of age with acute diarrhea in four sentinel hospitals were collected from Aug 2001 to July 2003. Specimens were tested and typed for rotavirus. Each child with rotavirus infection was assessed for severity of diarrhea according to the 20- points scoring system of Vesikari. Results When combined with P[8], the severity scores for rotavirus diarrhea of P[8] G1 and P[8] G3 were 13 and 12 points, respectively, and the durations of diarrhea were 6 days and 5 days, respectively. The percentage of fever in patients with diarrhea caused by P[ 8] G1 was higher than that in those with diarrheas caused by P[8]G3 （97% vs. 73% ） . And the highest temperature in the cases with diarrheas caused by G1 and G3 was 39~C and 38.6~C , respectively. When combined with G3, the difference of diarrhea severity scores between P [ 4] G3 and P[ 8 ] G3 was not significant. But duration of diarrhea caused by P[ 4] was longer than that of diarrheas caused by P[8] （6.5 days vs. 5 days） and the maximum times of vomiting in P[8] cases was higher than in P[4] cases （4 times vs. 3 times per day）. There was no significant difference in other clinical features between P[8] and P[4] infected cases. Conclusion When combined with P[8], RV diarrhea caused by G1 was associated with higher severity scores than diarrhea caused by G3. When combined with G3, there was no significant difference in severity scores between P[4] and P[8] infected cases.

关 键 词：轮状病毒属 血清分型 基因型 流行病学计量 

分 类 号：R686[医药卫生—骨科学]