羟丙基-β-环糊精用于静脉给药的研究概况  

Review of Hydroxypropyl-beta-cyclodextrin for intravenous administration

作　　者：王艳芝[1] 郑甲信[1] 毕殿洲[2] 邓意辉[2] 刘洋[1] 胡玉荣[1] 

机构地区：[1]郑州大学药学院,郑州450052 [2]沈阳药科大学药学院,沈阳110016

出　　处：《中国新药杂志》2007年第13期1010-1014,共5页Chinese Journal of New Drugs

摘　　要：羟丙基-β-环糊精是β-环糊精的一种化学修饰性衍生物,对于水难溶性药物具有良好的包合增溶效果。现对其理化性质、静脉给药后的毒性、药动学和组织分布的研究概况进行综述,并简要介绍其在国内外制剂中的使用情况,同时围绕静脉给药,对实际应用羟丙基-β-环糊精时需考虑的一些问题进行较详细的概述。Hydroxypropyl-beta-cyclodextrin （HP-β-CD）, a chemically modified β-CD deriva- tive, is an excellent solubilizer for poorly water-soluble drugs. Here we reviewed its physicochemical properties,toxicity,tissue distribution and pharmacokinetics after intravenous administration. Meanwhile, its application in pharmaceutics were summarized. Taking intravenous injection as an example, some points to be considered during HP-β-CD application were discussed in detail.

关 键 词：羟丙基-Β-环糊精 静脉给药 理化性质 安全性评价 

分 类 号：R944.9[医药卫生—药剂学]