大鼠三叉神经痛样反应模型的改进研究  

Amelioration of trigeminal neuralgia model in rats

作　　者：李丽[1] 李家伟[2] 张引成[2] 

机构地区：[1]西安医学院口腔医学系,陕西西安710021 [2]西安交通大学口腔医院颌面外科,陕西西安710004

出　　处：《延安大学学报（医学科学版）》2007年第2期1-2,共2页Journal of Yan'an University:Medical Science Edition

摘　　要：目的建立简单、可重复利用的三叉神经痛样动物模型。方法设计固位结构,在脑闩蛛网膜下腔留置插管,建立模型观察行为学反应。结果注药后大鼠发生三叉神经痛样反应,对照组无行为学反应。结论行为学反应明确,模型稳定,利于推广。Objective To found simple and repetitive model of trigeminal neuralgia in rats. Methods Injecting Penicillin K in the subarachnoid space at brain bolt through an intubatton with fixation in rats, observe the change in behavior. Saline was injected to the other group as a negative control. Result There has obviously reaction after the injection just like trigeminal neuralgia. The saline-control group has no reaction in behavior. Conclusion By this method, we can found simple and repetitive model of trigeminal neuralgia in rats. It＇s worth to be popularized.

关 键 词：三叉神经痛 动物模型 大鼠 

分 类 号：R322.8[医药卫生—人体解剖和组织胚胎学]