海南狗牙花化学成分研究  

Study on chemical constituents in rhigome of Ervatamia hainanensis

作　　者：梁爽[1] 陈海生[1] 金永生[1] 金丽[1] 卢嘉[1] 杜景伶[1] 

机构地区：[1]第二军医大学药学院,上海200433

出　　处：《中国中药杂志》2007年第13期1296-1299,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金资助项目(20272081)

摘　　要：目的:对海南狗牙花根茎的化学成分进行分离及结构鉴定。方法:利用各种色谱技术进行分离,根据理化性质及波谱学方法进行结构鉴定。结果:分离得到12个化合物,伏康京碱(voacangine,1),伊波加因(ibogaine,2),伊波加明(ibogamine,3),冠狗牙花碱(coronaridine,4),19-海尼山辣椒碱(19-heyneanine,5),19-表-海尼山辣椒碱(9-epi-heyneanine,6),3-羟基冠狗牙花碱(3-hydroxyl coronaridine,7),冠狗牙花羟基伪吲哚碱(coronaridine hydrox-yindolenine,8),3-(2-羰丙基)-冠狗牙花碱[3-(2-oxopropyl)coronaridine,9],老刺母碱(vobasine,10),α-香树醇(α-amyrin,11),α-香树酯醇乙酸酯(α-amyrin acetate,12)。结论:化合物1,2,6,11,12均为首次从该属植物中分离得到。Objective： To investigate the chemical constituents of the rhizome ofErvatamia hainanensis. Method： The solvent extraction and silica column chromatography were used to separate the chemical constituents, and their structures were identified by physico chemical properties and spectra analysis. Result： Twelve compounds were isolated and their structures were identified as voacangine （1）, ibogaine （2）, ibogamine （3）, coronaridine （4）, 19-heyneanine （5）, 19-epi-heyneanine （6）, 3-hydroxyl coronaridine （7）, coronaridine hydroxyindolenine （8）, 3-（2-oxopropyl） coronaridine （9）, vobasine （10）, α-amyrin （11）, α-amyrin acetate （12）. Conclusion： Compounds 1, 2, 6, 11 and 12 were first found from this plant.

关 键 词：海南狗牙花 化学成分 吲哚生物碱 

分 类 号：R284.1[医药卫生—中药学]