血府逐瘀汤对急性坏死性胰腺炎血流量和血液流变学的影响  

Effects of Chinese Medicine Xuefuzhuyuchang on blood flow of pancreas and hemorheology in acute necrotizing pancreatitis in rabbits

作　　者：曹光誉[1] 彭卫[1] 邹锦慧[2] 张慧明[2] 李道清 

机构地区：[1]韶关学院医学院附属新华医院中医科,512026 [2]韶关学院医学院解剖学教研室,512026 [3]韶关市中医院,512026

出　　处：《光明中医》2007年第7期74-77,共4页GUANGMING JOURNAL OF CHINESE MEDICINE

基　　金：广东省韶关市科技信息局资助项目(2006-37)

摘　　要：目的:探讨中药血府逐瘀汤对日本大耳兔急性坏死性胰腺炎(ANP)血液流变学、胰腺血流量及病理改变的影响。方法:逆行胰管注射5%的牛磺胆酸钠制作急性坏死性胰腺炎模型。于3、9、24h取标本观察各组血清酶学、血液流变学的改变,胰腺和回肠血流量的改变及胰腺的病理学形态改变。结果:与ANP组比较,中药治疗组血清淀粉酶由(4336.73±1482.27)IU/L降至(1942.79±621.36)IU/L(P<0.01);ANP组全血低切粘度、血浆粘度、红细胞压积、红细胞聚集指数、红细胞变性指数和红细胞电泳分别为9.64±2.52、3.27±0.54、51.43±11.42、2.92±0.73、0.94±0.23、7.65±1.96,而中药治疗组分别为7.78±2.73、1.72±0.25、42.75±8.86、2.23±0.63、0.78±0.12、5.66±1.86,与ANP组比较差异有显著性(P<0.05);中药治疗组胰腺和回肠的血流量分别为(0.509±0.103、0.454±0.068ml/min-1.g-1)与ANP组(0.353±0.084、0.303±0.086ml/min-1.g-1)比较有显著性差异(P<0.01)。中药治疗组胰腺间质水肿,炎性浸润减少,腺泡细胞胞浆空泡减少,胰腺实质可见少量出血和坏死,粒细胞聚集和粘附较少。结论:血府逐瘀汤具有显著改善大耳兔ANP血液流变学,增加胰腺和回肠血流量的作用。Objective ： To investigate the therapeutic effects of Chinese Medicine Xuefuzhuyuchang on blood flow of pancreas and hemorheology in acute necrotizing pancreatitis in rabbits. Methods ： Retrograde pancreatic duct injection of 5 % sodium taurocholate 1.0 ml· kg^-1 was used to establish ANP models. All rabbits were randomly divided into three groups： the control group （Group A, n = 15） ,the ANP group （Group B, n = 15） ,and the ANP with Chinese Medicine group （Group C, n = 15） .The levels of serum amylase, the changes of blood theology, the blood flow of pancreas and ileum and the pathology of pancreas were examined. Results： Compared with the Group B, animals in Group C showed reduction of amylases [ （4336.73 ± 1482.27）IU/L vs （1942.79 ± 621.36）IU/L, P 〈 0.01 ], the blood rheology indexes were significantly lower than those in Group B[ the whole blood viscosity at low shear rate was （7.78 ±2.73） vs （9.64±2.52）, P 〈 0.01 ; the plasma viscosity was （1.72 ± 0.25） vs （3.27 ± 0.54）, P 〈 0.01 ; the hematocrit was （42.75 ±8.86） vs （51.43 ± 11.42）, P 〈 0.01 ; the agglutination index of red blood cells was （2.23 ± 0.63 ） vs （2.92 ± 0.73）, P 〈 0.01; the transmogrification index of red blood cells was （0.78 ±0. 12） vs （0.94 ±0.23 ）, P 〈 0.05 ]; the electrophoresis index of red blood cells was （5.66 ± 1.86） vs （7.65 ± 1.96）, P 〈 0.01 ], in Group C, the blood flow in pancreas and ileum were significantly higher than those in Group B [pancreas： （ 0.509 ± 0 .103）ml/min^-1 ·g^-1 vs （0.353 ± 0.084） ml/min^-1 ·g^-1, p 〈 0.01 ,ileum： （0.454± 0.068） ml/min^-1· g^-1 vs （0. 303± 0. 086） ml/min ^-1·g ^-1 , p 〈 0.01 ], reduction of quantities of inflammatory cells infiltrated in the interstitial, reduction of quantities of vacuoles in the acinar cells. Conclusion ： Chinese Medicine Xuefuzhuyuchang can ameliorate the hemorheology and increase the blood flow of pancreas and ileum in acute nectrotizing pa

关 键 词：血府逐瘀汤/急性坏死性胰腺炎 血流量 血流变学影响 

分 类 号：R259[医药卫生—中西医结合]