钙蛋白酶10基因SNP-43与多囊卵巢综合征相关性研究  

Research on Association of Calpain10 Gene SNP-43 with Polycystic Ovary Syndrome

作　　者：孙雪琴[1] 石玉华[1] 高芹[1] 王来诚[1] 颜军昊[1] 陈子江[1] 

机构地区：[1]山东大学山东省立医院,山东济南250021

出　　处：《实用妇产科杂志》2007年第6期345-347,共3页Journal of Practical Obstetrics and Gynecology

基　　金：国家自然科学基金(30470703);山东省优秀中青年科学家科研奖励基金(连续资助项目)(03BS150)

摘　　要：目的:探讨钙蛋白酶10基因(CAPN10)的单核苷酸多态性SNP-43 G/A多态与多囊卵巢综合征(PCOS)患者发病的关系。方法:采用病例对照研究方法,以聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,对在山东省立医院生殖医学中心就诊的107例PCOS患者(PCOS组)和126例正常妇女(对照组)的CAPN10 SNP-43进行基因分型,并测定基础状态下的性激素水平及代谢指标。结果:SNP-43 G等位基因在PCOS组和对照组中的分布频率均为100%,未发现A等位基因,两组间比较差异无显著性(P>0.05)。结论:钙蛋白酶10基因SNP-43 G等位基因与多囊卵巢综合征的遗传易感性无明显相关性。Objective：To investigate the polymorphism of Calpain10 gene SNP-43 G/A in polycystic ovary syndrome （PCOS）. Methods ：107 PCOS patients （PCOS group） and 126 normal females （control group） from Center for Productive Medicine of Shandong Provincial Hospital were included in this case-control study, and the distribution of allele and genotype frequencies of SNP-43 in Calpain10 gene were detected with polymerase chain reaction-mstdction length polymocphism （PCR-RFLP）. The baseline sex hormone and metabolic parameters were measured meantime. Results： The distribution of G allele frequency of the SNP-43 was 100% in PC, OS group and control group, and A allele was not found in both group Cornparison between two groups was not significant （ P〉 0.05）. Conclusions：This study suggested that Calpain 10 gene SNP-43 may not contribute to the genetic susceptibility of PCOS.

关 键 词：多囊卵巢综合征 钙蛋白酶10基因 单核苷酸多态性 糖尿病 

分 类 号：R711.75[医药卫生—妇产科学]