妊娠期糖尿病妇女孕期持续性空腹高血糖的重要意义  

The Significance of Persistent Fasting Hyperglycemia in Gestational Diabetes Mellitus

作　　者：田静[1] 徐宜清[1] 蔡满红[1] 

机构地区：[1]南京医科大学附属妇幼保健院,江苏南京210004

出　　处：《实用妇产科杂志》2007年第6期360-362,共3页Journal of Practical Obstetrics and Gynecology

摘　　要：目的:研究妊娠期空腹高血糖和餐后高血糖分别与产后进一步发展为糖尿病(DM)之间的关系。方法:本研究随访了98例妊娠期糖尿病(GDM)患者,随访至产后8年,比较分析了仅需胰岛素治疗组、需使用夜间发挥作用的胰岛素组以及不需使用胰岛素组3者对产后发展为DM的几率的差别。结果:那些需要使用夜间发挥作用的胰岛素的GDM患者与不需要胰岛素治疗的参与者比较,前者更大可能产后发展为DM(RR=6.1,95%CI=2.8-14.2,P<0.01)。但那些仅仅需要使用餐前短效胰岛素的患者,与不需要使用胰岛素的患者相比,并没有更大可能性产后发展为DM(RR=1.4,95%CI=0.4-3.9,NS)。结论:因所使用的夜间发挥作用的胰岛素的用量可反映空腹血糖的水平,故推论出孕期出现持续性空腹高血糖的GDM患者,有更大的可能性产后进一步发展为DM。Objective：To study the relationship between fasting .and postprandial hyperglycemia during gestational period, with the development of subsequent diabetes mellitus （DM）. Methods： In this study, ninety- eight GDM patients were followed- up to 8 years after childbirth. We analyzed the risk that developing to subsequent DM among participants with only preprandial short- acting insulin needed, nighttime insulin needed, and no demand for insulin. Reaults：The participants need for nighttime intermediate- acting insulin had higher probability of the development of DM, when compared with those no demand for insulin （ RR 6.1,95% CI 2.8 - 14.2, P 〈 0.01 ）. However, there was no significant difference for risk to subsequent DM between those need preprendial insulin only and those no demand for insulin at all （RR 1.4, 95% CI 0.4 - 3.9, NS）. Conclusions： The GDM patient with persistent fasting hyperglycernia during gestational period has highly probability of the development of subsequent DM, as requirement for the nighttime insulin can actually reflect the degree of fasting hyperglycemia.

关 键 词：妊娠期糖尿病 糖尿病 空腹高血糖 胰岛素 

分 类 号：R714.256[医药卫生—妇产科学]