硼氢化钠在羧酸及其衍生物还原中的应用  

Application of Sodium Borohydride in the Reduction of Carboxylic Acid and Their Derivatives

作　　者：吕宏飞[1] 卞明[2] 张惠[1] 

机构地区：[1]黑龙江省石油化学研究院,黑龙江哈尔滨150040 [2]中国天辰化学工程公司黑龙江分公司,黑龙江哈尔滨150076

出　　处：《化学与粘合》2007年第4期284-288,共5页Chemistry and Adhesion

摘　　要：硼氢化钠可以很容易的将醛和酮还原为相应的醇,甚至可以在水介质中等当量的反应,但在温和条件下却很难将羧酸、羧酸酯、酰胺、酰氯和氨基酸及其衍生物还原,往往需要大大过量而且长时间回流,即使这样收率也很低。通过加入甲醇、路易斯酸、碘等修饰剂可以显著的提高硼氢化钠的活性,从而将羧酸及其衍生物还原为相应的醇。介绍了硼氢化钠还原羧酸及其衍生物的机理,综述了硼氢化钠在羧酸、羧酸酯、酰胺、酰氯和氨基酸及其衍生物还原中的应用。The aldehydes and ketones can be reduced readily by NaBH4 without any modification, even in water medium. NaBH4 can not reduce carboxylic acids, esters, amides, acid chloride, amino acids and their derivatives under ambient conditions, reflux and standing overnight are necessary. However, the activity of NaBH4 can be enhanced by the addition of additives such as I2、H2SO4、 lewis acid. In this article, the mechanism and the methods used for the reduction of carhoxylic acids, esters, amides, acid chloride, amino acids and their derivatives are described.

关 键 词：硼氢化钠 羧酸 修饰 还原 

分 类 号：TQ031.6[化学工程]