尖锐湿疣皮损组织细胞凋亡与P33ING1的关系  

Correlation of apoptosis to P33ING1 in the lesions of condyloma acuminatum

作　　者：贺琪[1] 毛先晴[2] 李科[1] 陈兴平[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院皮肤科,武汉430030 [2]武汉大学医学院病理生理教研室,430071

出　　处：《中国麻风皮肤病杂志》2007年第7期586-588,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的:探讨尖锐湿疣(CA)皮损组织细胞凋亡与P33ING1表达的关系。方法:取30例CA皮损和10例正常包皮的石蜡组织标本,分别采用TUNEL原位末端标记法检测其细胞凋亡、SABC免疫组化法检测其P33ING1的表达。结果:CA组细胞凋亡水平与正常对照组相比显著升高(P<0.05);CA组P33ING1蛋白与正常对照组相比呈现高表达(P<0.01);CA皮损中细胞凋亡指数与P33ING1指数呈显著正相关(r=0.654,P<0.005)。结论:CA皮损组织的细胞凋亡可能与P33ING1蛋白的过度表达有关。Objective： To determine the correlation of apoptosis to P33ING1 in the lesions of condyloma acuminatum （CA）. Methods： Apoptosis cells in situ and P33ING1 expression were measured with terminal - deoxynucleotidyl transferase mediated nick and labeling （TUNEL） and SABC immunohistochemieal staining in paraffin sections of 30 CA tissues and 10 normal foreskins. Results： Apoptosis index （AI） and the expression of P33ING1 in CA eases were significantly higher than those in normal tissues （ P 〈 0.05 and P 〈 0.01 ）. There was a positive correlation between apoptosis and P33ING1 in CA samples （ r = 0.654, P 〈 0.005）. Conclusion： In CA keratinocyte, apoptosis may be related to the high expression of P33ING1.

关 键 词：尖锐湿疣 人乳头瘤病毒 凋亡 P33ING1 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]