儿童非酒精性脂肪性肝病研究进展  

Nonalcoholic fatty liver disease in children

作　　者：张晓燕[1] 陈莉明[2] 

机构地区：[1]天津市妇女儿童保健中心健康检测中心,300070 [2]天津医科大学代谢病医院糖尿病肾病科,300070

出　　处：《国际内分泌代谢杂志》2007年第4期231-234,共4页International Journal of Endocrinology and Metabolism

摘　　要：非酒精性脂肪性肝病(NAFLD)是导致儿童及青少年肝病的最常见原因。近年来,由于肥胖症的发病率逐年升高,NAFLD的患病率也明显增加。对于非酒精性脂肪性肝炎(NASH)的确诊及分级依赖于组织活检。一些非创伤性的检测指标及影像技术的发展有助于在NAFLD高风险人群中进行大范围筛查。在儿童患者中存在两种组织类型不同的NASH,其临床特征及人群特征也有差异。至今并未有儿童NAFLD的最佳治疗方案,但研究人员认为生活方式干预如饮食控制或锻炼具有一定作用。维生素E和二甲双胍对儿童NAFLD的治疗作用正处于临床研究之中。Nonalcoholic fatty liver disease （NAFLD） is probably the most common cause of liver disease in the preadolescent and adolescent age groups. There seems to be an increase in the incidence of NAFLD, likely related to the dramatic rise in the prevalence of obesity during the past 3 decades. Accurate diagnosis and staging of nonalcoholic steatohepatitis （NASH） requires liver biopsy. The development of noninvasive surrogate markers and the advancements in imaging technology will aid in the screening of large populations at risk for NAFLD. Two distinct histological patterns of NASH have been identified in the pediatric population, and discrete clinical and demographic features are observed in children with these 2 patterns. While the optimal treatment of pediatric NAFLD has yet to be determined, lifestyle modification through diet and exercise should be attempted in children diagnosed with NAFLD. A large, multicenter trial of vitamin E and mefformin is underway as part of the NASH clinical research network.

关 键 词：非酒精性脂肪性肝病 非酒精性脂肪性肝炎 肥胖症 胰岛素抵抗 儿童 

分 类 号：R725.7[医药卫生—儿科]