乙基西梭霉素的药物动力学  

Study on pharmacokinetics of netilmicin in guineas

作　　者：沈金芳[1] 王平全[1] 

机构地区：[1]上海第二医科大学附属仁济医院

出　　处：《中国医院药学杂志》1997年第4期150-151,共2页Chinese Journal of Hospital Pharmacy

摘　　要：以荧光偏振免疫方法对豚鼠肌内注射乙基西梭霉素后血浆及外淋巴的药物动力学进行研究，其药动学过程符合二室开放模型，在血浆中的主要药动学参数Ｋａ为２６．９８ｈ－１，Ｋｅ为１．４２ｈ－１，Ｔ１／２β为０．６８３ｈ，Ｔｍａｘ为０．３２５ｈ，Ｃｍａｘ为３５２．４５μｇ／ｍｌ；在外淋巴液Ｋａ为１．２９ｈ－１，Ｋｅ为０．１２６ｈ－１，Ｔ１／２β为１５．９７ｈ，Ｔｍａｘ为１．３７ｈ，Ｃｍａｘ为９．０４μｇ／ｍｌ。结果表明：乙基西梭霉素在外淋巴消除缓慢，半衰期显著大于血浆半衰期。fter guineas were given with netilmicin 100mg·kg -1 intramuscularly,plasma and perilymph concentration of netilmicin was determined by FPIA.The concentration time curve of netilmicin in guineas was shown to fit a two compartment open model.The main pharmacokenetic parameters was K a = 26.98 h -1 , K e = 1.42 h -1 , T 1/2β = 0.683 h, T max = 0.325 h, C max = 352.45 μg/ml in plasma and K a = 1.29 h -1 , K e = 0.126 h -1 , T 1/2β = 15.97 h, T max = 1.37 h, C max = 9.04 μg/ml.The results showed that netilmicin elimiated slowly in perilymph and its half life was longer than the half life in plasma significantly.

关 键 词：乙基西梭霉素 血浆 药物动力学 抗菌素 

分 类 号：R978.12[医药卫生—药品]