α-细辛脑在人体的生物利用度研究  

Absolute bioavailability of synthetic asarone in healthy volunteers

作　　者：杨正鸿[1] 吴闯[1] 

机构地区：[1]广西医科大学第一附属医院

出　　处：《中国医院药学杂志》1997年第4期165-167,共3页Chinese Journal of Hospital Pharmacy

摘　　要：本文报道α－细辛脑的人体生物利用度。１２名健康受试者单剂量用药后，ＨＰＬＣ法测定血药浓度，结果片剂和胶囊剂的绝对生物利用度仅５．５６％和２．７３％，有必要改进生产工艺和处方组成。his paper reported the bioavailability of synthetic asarone (the trans form of 2,4,5 trimethoxy 1 propenyl benzene) in healthy volunteers.After a single intravenous dose of 16mg and oral dose of 120mg,the serum concentration of asarone was determined by HPLC in 12 healthy volunteers.The absolute bioavailability of synthetic asarone tablets and capsules were both very low, 5.56% and 2.73% respectively.It is possible that the poor absolute bioavailability of synthetic asarone be caused by its poor dissolution in water.The results showed that the mean serum concentration time curve following oral and intravenous administration were two and three compartment model respectively.

关 键 词：Α-细辛脑 生物利用度 呼吸系统药 高效液相色谱 

分 类 号：R974[医药卫生—药品] R969.1[医药卫生—药学]