大鼠脑内第三脑室前腹侧区降压功能的中枢机制  

Central neural mechanism of anteroventral third ventricle region depressor area in rat brain

作　　者：李耀华[1] 顾蕴辉[2] 

机构地区：[1]大理学院生理学与病理生理学教研室,云南大理671000 [2]北京大学医学部生理系,北京100083

出　　处：《大理学院学报（综合版）》2007年第6期21-23,32,共4页Journal of Dali University

基　　金：云南省教育厅科研基金资助项目(02ZY136)

摘　　要：目的:为了验证ANP能神经是否从第三脑室前腹侧区(AV3V)投射到血管紧张素Ⅱ(AⅡ)升压系统。方法:用脑内微量注射药物,观察动脉血压和心率变化的方法。结果:①心房钠尿肽(APeⅢ)分别注入SFO,LH/PF,NPV和RVL后,引起血压下降。②在SFO,双侧的LH/PF,NPV和RVL预注射A71915(一种心房钠尿肽III的抑制剂),产生谷氨酸兴奋AV3V的相反效应。结论:刺激AV3V的心房钠尿肽能神经,可分别在LH/PF-SFO-NPV-RVL的血管紧张素Ⅱ(AⅡ)升压系统引起降压效应。A71915注入以上核团可反转AV3V的降压效应。Objective： To examine whether ANP ergic projections from the AV3V could act upon nuclei involved in the AⅡ pressor system. Method： Changes in arterial pressure and heart rate were observed by using intrabrain microinjection of drugs. Results： ① Injection of atriopeptin m into either the LH/PF, SFO, NPV or RVL induced a depressor response; ② preinjection of A71915 （an atriopeptin Ⅲ antagonist） into either bilateral LH/PF, SFO, bilateral NPV or RVL reversed the depressor response of the AV3V to glutamate. Conclusion： The results indicate that excitation of atriopeptinergic neurons in the AV3V produces an inhibitory effect on each nucleus in the LH/PF-SFO-NPV-RVL A Ⅱ pressor system. A71915 injection into any one of these nuclei can reverse the AV3V depressor response.

关 键 词：脑 第三脑室前腹例区 降压反应 

分 类 号：R338[医药卫生—人体生理学]