维生素C对减轻糖尿病大鼠肾脏损害的作用  

EFFECT ON VITAMIN C ON PRESERVATION OF RENAL FUNCTION IN STREPTOZOCIN-INDUCED DIABETIC RATS

作　　者：黄宇峰[1] 周江华[1] 林善锬[1] 程海芬 

机构地区：[1]上海医科大学华山医院肾病研究室,200040

出　　处：《上海医科大学学报》1997年第2期100-102,共3页Journal of Fudan University(Medical Science)

基　　金：国家卫生部科研基金

摘　　要：以链脲佐菌素（STZ）腹腔注射SD大鼠建立糖尿病动物模型，口服补充维生素C8周，调查维生素C对糖尿病肾脏损害的干预作用。结果发现补充维生素C在不影响血糖水平的基础上，使糖尿病大鼠升高的糖化血红蛋白（GNb）水平下降了27．28％［（5．73±0．53）％与（7．71±0．22）％P＜0．05）］，使糖尿病状态下明显增加的肌酐清除率水平（Ccr）得到轻度改善，使糖尿病大鼠的微量蛋白尿明显缓解。提示补充维生素C对糖尿病大鼠的肾脏损害有一定的保护作用，其作用机制可能是通过降低蛋白非酶糖化的速率，从而在一定程度上阻止蛋白非酶糖化所致的病理作用而实现的。PURPOSE The aim was to investigate the effect of vitamin C on renal damage in SD rats with streptozoci-ninduced diabetes.METHODS Four groups of rats, control rats with and without Vc treatment, diabetic rats without Vc treatment and diabetic rats which received Vc were followed up for 8 wk, with 4 weekly measurments of urinary albumin excretion by means of RIA. The levels of glycosylated hemoglobin (GHb) were evaluated with on ex-change chromatography.RESULTS 8 wk after the onset of diabetes, significant increases of GHb level (D vs. C1 7.71±0.22 % vs2.95±0.52 % P< 0.001 ) and blood glucose （BG） level （D vs. C1 29.33±2. 18 vs 5.90 ±0.71 mmol / L P< 0.001 ) were observed. Vitamin C adminstration did not cause any significant change in BG level throughout the study,but in diabetic rats, it affected the GHb concentration which was decreased by 27.28 % (P< 0.05) as compared with that in untreated diabetic rats. In addition, diabetes was associated with increases creatinine clearence rate (Ccr) and the level of albuminuria. Vitamin C can ameliorate the increase of Ccr and attenuate the rise of albuminuria in diabetic rats.CONCLUSIONS Vitamin C administration decreases the rate of protein glycation, which may be of use in the prevention of diabetic renal damage.

关 键 词：维生素C 糖基化 糖尿病 肾脏损害 防治 

分 类 号：R587.2[医药卫生—内分泌] R977.23[医药卫生—内科学]