化合物疏水参数测定的脂质体毛细管电泳方法  

Method Measuring of Hydrophobic Parameter of Organic Compounds via a Novel Liposome Capillary Electrophoresis

作　　者：董志强[1] 夏之宁[1] 蒋雪梅[2] 

机构地区：[1]重庆大学化学化工学院药学系,重庆400030 [2]重庆大学生物工程学院,重庆400030

出　　处：《高等学校化学学报》2007年第7期1273-1275,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20375051);教育部高校青年教师奖(批准号:教人司[2002]123)资助

摘　　要：Liposome capillary electrophoresis(LCE) provides a novel and facile approach for determining hydrophobic parameters(lgP) of organic compounds.In order to avoid the error of the migration time of liposome phase(tl) on determination,a novel technique was developed in this paper,in which the tl was obtained via non-linearity fitting with lgP values from literatures and migration time(tm) of a series of standard compounds.lgP values of the six benzene derivatives determined by this LCE method were compared with literature values and the ones obtained by directly determined tl and MEEKC.The average error between lgP values determined by two LCE methods was 0.07 logarithm units.The LCE method was simple and rapid,which can provide a new way to determine lgP of organic compounds.Liposome capillary electrophoresis（LCE） provides a novel and facile approach for determining hydrophobic parameters（lgP） of organic compounds. In order to avoid the error of the migration time of liposome phase（t1） on determination, a novel technique was developed in this paper, in which the t1 was obtained via non-linearity fitting with lgP values from literatures and migration time（tm） of a series of standard compounds. lgP values of the six benzene derivatives determined by this LCE method were compared with literature values and the ones obtained by directly determined t1 and MEEKC. The average error between lgP values determined by two LCE methods was 0. 07 logarithm units. The LCE method was simple and rapid, which can provide a new way to determine lgP of organic compounds.

关 键 词：脂质体 毛细管电泳 疏水参数 迭代拟合 

分 类 号：O657[理学—分析化学]