3-氧-11,12,13-三羟基桉烷-4-烯的简便全合成  

Facile Total Synthesis of 3-Oxo-11,12,13-trihydroxyeudesm-4-ene

作　　者：关玉昆[1] 房丽晶[2] 唐志勇[2] 李裕林[2] 

机构地区：[1]烟台大学药学院,烟台264005 [2]兰州大学功能有机分子化学国家重点实验室,兰州730000

出　　处：《高等学校化学学报》2007年第7期1307-1309,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20272021);烟台大学博士科研启动基金资助

摘　　要：3-Oxo-11,12,13-trihydroxyeudesm-4-ene(1) was a highly oxygenated natural eudesmane isolated from traditional herbal medicine with an antiphlogostic and spasmolytic activity.For the purpose of pharmacological activity research on natural product 1 and its derivatives,a facile total synthesis of compound 1 starting from(+)-dihydrocarvone(2) was completed in an overall yield of 24%.The structures of all intermediates and product 1 were confirmed via 1H NMR,13C NMR,MS and IR techniques.The NMR data of compound 1 are in agreement with those of natural products.3-Oxo-11,12,13-trihydroxyeudesm-4-ene （ 1 ） was a highly oxygenated natural eudesmane isolated from traditional herbal medicine with an antiphlogostie and spasmolytie activity. For the purpose of pharmacological activity research on natural product 1 and its derivatives, a facile total synthesis of compound 1 starting from （ ＋ ）-dihydroearvone（2） was completed in an overall yield of 24%. The structures of all intermediates and product 1 were eortfirmed via 1H NMR, is C NMR, MS and IR techniques. The NMR data of compound 1 are in agreement with those of natural products.

关 键 词：桉烷 3-氧-11 12 13-三羟基桉烷-4-烯 全合成 倍半萜 

分 类 号：O621.3[理学—有机化学]