Synonymous codon usage in Methanosarcina mazei str.Goe1 and other Euryarchaeota microorganisms  

甲烷八叠球古菌及其他广古菌同义密码子使用偏好性(英文)

作　　者：吴昊男[1] 笪遥[1] 魏镓伟[1] 江澎[1] 陆祖宏[1] 

机构地区：[1]东南大学生物电子学国家重点实验室,南京210096

出　　处：《Journal of Southeast University(English Edition)》2007年第2期289-293,共5页东南大学学报（英文版）

摘　　要：A comparative analysis of the codon usage bias was conducted in Methanosarcina mazei str. Goel and two related Euryarchaeota microorganisms （Picrophilus torridus str. DSM 9790 and Natronomonas pharaonis str. DSM 2160）. Results revealed that synonymous codon usage in Methanosarcina mazei str. Goel was less biased, which was highly correlated with the GC3S value. And the codon usage patterns were phylogenetically conserved among those Euryarchaeota microorganisms. By employing a hierarchical clustering analysis, it can be seen that it is more the species than the gene function that determines their gene codon usage pattems. Considering that those microorganisms live in different environments where the pH conditions vary quite a lot, it can be presumed that their living environments, especially the pH conditions, play an important role in determining those microorganisms＇ codon usage pattems.比较分析了甲烷八叠球古菌(Methanosarcina mazei str.Goe1)和其他2种系统发育相关的广古细菌(嗜苦古菌(Picrophilus torridus str.DSM9790)和盐碱古菌(Natronomonas pharaonis str.DSM2160))的同义密码子使用偏好性.结果表明甲烷八叠球古菌的密码子使用偏好性很小,并且与GC3S值有很高的相关性.这3种广古细菌的密码子使用模式在进化上很保守.通过分层聚类分析,得出较之基因功能对密码子使用的影响,这些广古菌密码子的使用更是由其物种所决定的.考虑到这3个物种生活在pH值差异很大的环境中,推测其生活环境在很大程度上决定了这些微生物密码子的使用方式.

关 键 词：codon usage bias relative synonymous codon usage （RSCU） methanosarcina mazei str. Goel 

分 类 号：Q617[生物学—生物物理学]