动脉压力感受性反射对盲肠结扎穿孔致脓毒症大鼠生存率的影响  

Effect of arterial baroreflex on survival rate of rats with cecal ligation and puncture-induced sepsis

作　　者：史克勇[1] 马秀娟[1] 曹颖林[1] 张伟 沈甫明[2] 

机构地区：[1]沈阳药科大学药学院,沈阳110016 [2]第二军医大学药学院药理学教研室,上海200433

出　　处：《第二军医大学学报》2007年第7期705-708,共4页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(30330650).~~

摘　　要：目的:观察动脉压力感受性反射(ABR)对盲肠结扎穿孔(CLP)致脓毒症大鼠生存率的影响。方法:利用破坏反射弧的方法,将雄性大鼠依据反射功能高低分为两组:假手术大鼠(n=22)和去窦弓神经(SAD)大鼠(n=22)。用CLP致大鼠脓毒症模型,采用计算机化清醒大鼠血压连续监测技术,于CLP后动态监测大鼠的血压及心动间期,并观察大鼠12h内的存活情况。结果:大鼠CLP后收缩压和舒张压随时间逐渐下降,而心动间期则先变短再急剧变长直至动物死亡。12h后假手术大鼠的生存率为86%,而SAD大鼠的生存率为59%,两组大鼠Kaplan-Meier生存曲线存在显著差异(P<0.05)。结论:ABR在CLP致大鼠脓毒症中起重要作用。Objective：To investigate the effect of arterial baroreflex （ABR） on survival rate of rats with cecal ligation and puncture （CLP）-induced sepsis. Methods： Male Sprague -Dawley rats were divided into 2 groups., sham-operated rats （n=22） and sinoaortic denervated （SAD） rats （n= 22）. Four weeks after SAD rats were subjected to CLP-induced sepsis, the blood pressure and heart period （HP） were monitored for 12 hours in conscious state and the survival of rats was observed. Results.. Both the diastolic and systolic blood pressue gradually decreased after CLP. the HP shortened first and then drastically prolonged until the death of rats. At 12 h after CLP the survival rate of SAD rats was lower than that of the sham operated rats （59 % vs 86%）. Significant differences were found between the Kaplan-Meier survival curves of the rats in 2 groups（P〈0.05）. Conclusion： ABR plays an important role in CLP-induced lethal sepsis model.

关 键 词：盲肠结扎穿孔 脓毒症 压力感受器反射 去窦弓神经 生存率分析 

分 类 号：R339.17[医药卫生—人体生理学]