不同年龄段乳腺癌临床病理特征分析  

Analysis on pathological characteristics of breast cancer at different ages

作　　者：李金平[1] 刘奇伦[1] 吴立刚[1] 

机构地区：[1]宁夏医学院附属医院,宁夏银川750004

出　　处：《宁夏医学杂志》2007年第7期590-592,共3页Ningxia Medical Journal

摘　　要：目的比较不同年龄段乳腺癌患者临床病理方面的特点,以探讨各年龄段之间的病理差异。方法将454例浸润性乳腺癌患者分为青年组(≤35岁),中年组(36-59岁),老年组(≥60岁),比较不同年龄段患者的病理分期、淋巴结转移及雌、孕激素受体(ER、PR)表达等临床病理特点。结果3组乳腺癌的淋巴结转移率青年组明显高于中老年组,差异有显著性(P<0.05)。病理分期青年组乳腺癌Ⅲ期病例明显高于中老年组,有统计学意义(P<0.05)。在激素受体方面,青年组ER、PR阳性率明显低于中老年组,而Cer-b-2表达明显高于中老年组,差异有统计学意义(P<0.05)。中年组和老年组间的各项观察指标比较差异无统计学意义。结论青年乳腺癌具有侵袭性强、生长快、恶性度高、易转移、病期晚的特点。Objective To study and compare the pathological characteristics of breast cancer at different ages. Methods 454 patients were classified as follows： adolescent group （ ≤35years）, adult group （36 -59years） and old aged group （≥60years）. Pathological characteristics of all patients such as TNM staging, axillary lymph nodes and estrogend and progesteron receptors （ER, PR） expression were recorded and compared.. Results TNM staging and the positive rate of axillary lymph nodes in youth were significantly higher than those in adult group and old aged group （ P 〈 0.05 ）. The positive rates of ER and PR in the adolescent group were significantly lower than those in adult and old aged groups （ P 〈 0.05 ） , whereas the positive rates of Cer - b - 2 in the adolescent group were significantly higher than that in those groups （ P 〈 0.05 ）. There wasnt statistical differnce in all items between adult group and old aged group. Conclusion Younger patients with breast cancer has the feature of strong invasion, rapid growth, high grade malignantly, early metastasis and usually has later course of diseases.

关 键 词：乳腺癌 激素受体 

分 类 号：R737.9[医药卫生—肿瘤]