创伤-失血性休克与细胞免疫功能的临床研究  

Study on cellular immune function in patients with traumatic-hemorrhagic shock

作　　者：马少林[1] 王晓红[1] 杨晓军[1] 丁欢[1] 曹相原[1] 

机构地区：[1]宁夏医学院附属医院,宁夏银川750004

出　　处：《宁夏医学杂志》2007年第7期605-606,共2页Ningxia Medical Journal

摘　　要：目的探讨创伤-失血性休克后患者早期细胞免疫功能是否受到损害。方法分别采集入住ICU24-48小时内27例创伤-失血性休克和24例非休克患者外周静脉血,采用流式细胞仪进行外周血淋巴细胞亚群分析。结果创伤-失血性休克患者总T淋巴细胞百分比较非休克组患者明显减低(P<0.01);其中辅助T淋巴细胞(CD3+,CD4+)、抑制T淋巴细胞(CD3+,CD8+)百分比较非休克对照组患者减低;但B淋巴细胞(CD19+)百分比创伤休克组较非休克组高(P均<0.01);NK细胞(CD16+/CD56+)两组间无明显异常(P>0.05)。结论创伤-失血性休克后患者早期细胞免疫功能即受到明显抑制,这可能是造成创伤-失血性休克患者后继发感染的原因之一。Objective To investigated the cellular immune function that was inhibited after occurring the traumatic hemorrhagic shock. Methods The whole blood samples were collected from 27 patients after occurring traumatic hemorrhagic shock and 24 non - shock patients, respectively. After administrated 24 to 48 hours in ICU, the lymphocyte subsets of whole blood samples were assessed with flow cytometry （FCM）. Results CD3 ^＋ in patients with traumatic hemorrhagic shock was lower than that in patients with non - shock; either CD3 ^＋ , CD4 ^＋ or CD3 ^＋ , CD8^＋ was lower compared to that in non - shock patients. CD19 ^＋ in patients with traumatic hemorrhagic shock was higher compared to that in non - shock. Conclusion The cellular immune function is significantly inhibited after occurring the traumatic - hemorrhagic shock, which may result in the subsequent inflammation on the late stage.

关 键 词：创伤 休克 细胞免疫 淋巴细胞亚群 

分 类 号：R641[医药卫生—外科学]