复方银杏叶片对大鼠的长期毒性研究  

The Long-term Toxicity Study of Compound Ginkgo Biloba Tablets in Rats

作　　者：潘洪平[1] 危华玲[1] 陈英[1] 钟正贤 陈学芬 李燕婧 路玫[1] 

机构地区：[1]广西壮族自治区人民医院,广西南宁530021 [2]广西壮族自治区中医药研究所,广西南宁530022

出　　处：《时珍国医国药》2007年第7期1572-1574,共3页Lishizhen Medicine and Materia Medica Research

基　　金：广西壮族自治区科学基金项目(No.0342003-1)

摘　　要：目的观察复方银杏叶片对大鼠长期毒性影响。方法复方银杏叶片88.44,17.69 mg/kg(为临床日剂量的50倍和10倍)给大鼠连续灌服13周,停药2周,分别测量大鼠体重,计算脏器系数,测定血液学和血液生化学指标,并作组织病理学检查。结果复方银杏叶片高、低剂量组大鼠的外观体征、行为活动、体重、脏器系数、血液学和血液生化学指标,与空白对照组比较,均无明显差异;病理检查未见与药物毒性相关的明显病变,停药后也未见药物延迟性毒性反应。结论复方银杏叶片长期用药对大鼠无明显毒性,推论临床拟用剂量应是安全的。Objective To observe the effects of compound Ginkgo biloba Tablets on rats. Methods 60 rats were randomly divided into 3 groups, each group was given compound Ginkgo biloba tablets intragastrically in dose of 88.44,17.69 mg/kg （50 and 10 times of clinic dose） for 13 weeks. Half of the animals were killed immediately after the last administration, and another haft of rats were observed for 2 weeks after medicine withdraw. Parameters were examining including general condition, body weight, food intake, blood cell, blood biochemistry, organ index, and histopathological examination. Results The outer appearance and behavior, weights, organ coefficient, the indexes of haematology and biochemistry in rats had no significant difference by comparing with control group. The pathological examination did not discover significant pathological changes related to drug toxicity and the delayed toxicity reaction after drug administration. Conclusion Compound Ginkgo biloba Tablets has no significant toxicity for long - term administration to rats. It infers that the drawing up doses in clinic will be safe.

关 键 词：复方银杏叶片 大鼠 长期毒性实验 

分 类 号：R285.5[医药卫生—中药学]