健骨冲剂对去卵巢骨质疏松大鼠血清ALP,NOS活性及NO含量的影响  

Changes of Serum ALP,NO and NOS in Osteoporosis Model Rats Treated with JianGu Granule

作　　者：张洋[1] 李亚东[1] 李健男[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《时珍国医国药》2007年第7期1651-1652,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的观察健骨冲剂对去卵巢雌性骨质疏松大鼠血清碱性磷酸酶(ALP)、一氧化氮合酶(NOS)活性及一氧化氮(NO)含量的影响。方法以去卵巢雌性大鼠骨质疏松为模型,通过给药60 d后,与模型对照组比较血清ALP,NOS活性和NO含量。结果健骨冲剂组大鼠血清ALP,NOS活性及NO含量明显高于模型组(P<0.01)。结论中药健骨冲剂能显著提高血清ALP,NOS活性及NO含量,从而作用于成骨细胞促进骨形成,调节骨重建过程。Objective To observe the changes of serum ALP, NO and NOS in the ovarieetomized osteoporosis rats treted with Jiangu granule （JGCJ） . Methods After fed for 60 days, the ovarieetomized rats group with JGCJ were examined and compared with the group without JGCJ. Results The levels of ALP, NO and NOS in group with JGCJ were significantly higher than those of the group without JGCJ. Conclusion The Chinese medicine JGCJ can significantly increase the level of ALP, NO and NOS in the ovariectomized model rats＇serum, facilitate formation of bone cell and adjust restructure of bone.

关 键 词：健骨冲剂 骨质疏松 碱性磷酸酶 一氧化氮合酶 一氧化氮 

分 类 号：R285.5[医药卫生—中药学]