肾病患儿中药治疗前后超氧化物歧化酶的变化  

Changes in Blood Superoxide Dismutase before and after Treatment of Chinese Drugs in Patients with Nephrosis

作　　者：毛春华[1] 林建荣[1] 

机构地区：[1]黄石理工学院医学院,湖北黄石435003

出　　处：《时珍国医国药》2007年第7期1737-1738,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的观察益肾活血中药对肾病的疗效。方法68例肾病患儿随机分为治疗组与对照组各34例,治疗组在对照组治疗基础上加用益肾活血药。测定治疗前后超氧化物歧化酶(SOD)及血清过氧化脂质(LPO)含量的变化,分别与30名健康儿童作比较。结果肾病患儿SOD明显低于健康儿童组(P<0.01),而LPO明显高于健康儿童组(P<0.01)。治疗4周后治疗组SOD水平明显升高(P<0.01),LPO明显下降,与对照组相比有显著性差异(P<0.01)。结论益肾活血药对抗过氧化损伤、防治肾病有一定临床意义。Objective To observe the curative effect of chinese drugs for reinforcing the kidney and promoting blood circulation on nephrosis. Methods Sixty -eight cases of nephrosis were divided into treatment group and control group, the reinforcing the kidney and promoting blood circulation was applied to treatment group on the base of control group treatment. Then changes of serum superoxide dismutase （SOD） and lipid perixidatio （LPO） were compared between the two groups. Results The serum SOD level in nephrosis patients was lower than that in healthy children （P 〈 0.01 ） , but the serum levels of LPO were higher in nephrosis patients than in healthy children （P 〈 0.01 ）. After four - week treatment, the serum level of SOD increased obviously（ P 〈 0.01 ）. The serum levels of LPO decreased obviously in treatment group. There were significant difference between the two group（ P 〈 0. 01 ）. Conclusion Chinese drugs forreinforcing the kidney and promoting blood circulation can increase the activity of SOD to antagonice peroxide - induced damage, and therefore can treat the weakness of kidney.

关 键 词：肾病 益肾活血药 超氧化物歧化酶 

分 类 号：R259[医药卫生—中西医结合]