子宫内膜异位症患者血清环氧化酶-1含量测定及临床意义  

Serum Soluble Cell Adhesion COX-1 in Endometriosis

作　　者：苍亚芹 赵俊华 

机构地区：[1]黑龙江省鹤北林业局职工医院,黑龙江鹤北154200

出　　处：《黑龙江医学》2007年第7期481-482,共2页Heilongjiang Medical Journal

摘　　要：目的探讨子宫内膜异位症（内异症）患者血清环氧化酶-1（COX-1）水平的变化及其临床意义。方法采用双抗夹心酶联免疫吸附法（ELISA）测定68例内异症患者（其中,Ⅰ-Ⅱ期10例、Ⅲ-Ⅳ期58例）及56例对照组血清COX-1以及4例内异症复发患者COX-1水平的变化。结果内异症组血清COX-1的水平高于对照组,差异有显著性（P〈0.05）。其中,内异症Ⅲ、Ⅳ期与对照组相比,差异有显著性（P〈0.05）和极显著性（P〈0.01）;内异症患者血清COX-1水平于手术治疗前后比较,差异有极显著性（P〈0.01）。结论COX-1在内异症的发生发展中起重要作用,血清COX-1可望成为内异症诊断和手术治疗监测更有价值的免疫学指标。Objective To evaluate the changes of serum soluble cell adhesion COX - 1 in endometriosis（EMs） and their clinical significance.Methods The COX- 1 and CA125 levels in serum of 68 endometriotic patients（ 10 womenwithstage Ⅰ and Ⅱ, 58 womenstage Ⅲ and Ⅳ ） and 56 control patients were determined by ELISA, and the serum changes were measured by ELISA before and after conservative laparoscopic surgery in patients with EMs. Results The serums COX - 1 levels in EMs were higher than those in control women（ P 〈0.05）.And serums COX- 1 levels in stage m or iV of EMs were higher or significantly higher than those in control group（ P 〈 0.05 or P 〈 0.01） .Signific antparallel relationship existed between the stage of EMs and the serums COX - 1 levels in EMs patients （rvalue： 0. 594, P 〈 0.01）. After clearance of endometriosisfoci with laparoscopic conservative surgery,the serums COX- 1 levels decreased significantly （ P 〈 0.01）. Conclusion The COX- 1 may play animpartantrole in the pathogenesis and progression of EMs. Serum COX- 1 may be regarded as asignificant diagnostic or the rapeutic indexin EMs.

关 键 词：子宫内膜异位症 环氧化酶-1 CA-125 血清 

分 类 号：R711.71[医药卫生—妇产科学]