血清氧化应激指标与早期糖尿病肾病及代谢综合征的关系  

Relationship between serum markers of oxidative stress and early stage diabetic nephropathy as well as metabolic syndrome

作　　者：干军[1] 冯雨[1] 徐宽枫[1] 冯玉兰[2] 刘翠萍[1] 刘超[1] 

机构地区：[1]南京医科大学第一附属医院内分泌科 [2]马鞍山市人民医院内分泌科,安徽马鞍山243000

出　　处：《临床荟萃》2007年第14期998-1000,共3页Clinical Focus

基　　金：江苏省政府医学重点学科资助项目(SK-2002-14)

摘　　要：目的探讨伴代谢综合征(metabolic syndrome MS)、2型糖尿病(T2DM)及早期糖尿病肾病(diabeticnephropathy DN)患者中氧化应激的变化情况。方法将T2DM患者112例分为单纯T2DM组、T2DM伴早期DN组、T2DM伴MS组、T2DM伴MS并早期DN组,同时设有30例正常对照组,测定各组的血清丙二醛(MDA)及总抗氧化能力(T-AOC)水平。结果与正常对照组比较T2DM各组中氧化应激水平均明显升高,其中伴MS组与不伴MS组比较T-AOC下降(13.7±2.0)kU/L、(10.6±1.1)kU/L vs(16.7±1.6)kU/L、(14.6±1.8)kU/L,MDA升高(5.5±0.8)nmol/L、(6.8±1.2)nmol/L vs(4.7±0.9)nmol/L、(5.3±0.6)nmol/L(均P<0.01),早期DN组与无早期DN组比较T-AOC下降、MDA升高(均P<0.01),伴MS早期DN组T-AOC下降、MDA升高最为明显。结论T2DM中抗氧化能力均相对或绝对减弱,而在合并MS及早期DN患者中更加重抗氧化能力的损伤,临床应用抗氧化药物治疗可能有一定疗效。Objective To investigate the level of oxidative stress in type 2 diabetes（T2DM）with metabolic syndrome（MS） and early stage diabetic nephropathy（DN）. Methods One hundred and twelve patients were divided into different groups with T2DM,T2DM with early stage DN, T2DM with MS, T2DM with early stage DN and MS. Thirty normal persons were chosen as control group. The levels of serum total anti-oxidation capability（T-AOC） and malondiadehyde（MDA） were tested in all the subjects. Results The patients with T2DM in different groups all showed higher oxidative stress. In comparison between MS group and non-MS group, T-AOC was lowered, （13.7 ± 2.0） kU/L, （ 10.6± 1.1 ） kU/L vs （ 16.7± 1.6 ） kU/L, （ 14.6 ±1.8） kU/L, but MDA was increased, （ 5.5±0.8 ） nmol/L, （6.8±1.2） nmol/L vs （4.7±0.9） nmol/L, （5.3±0.6） nmol/L（all P〈0.01）. The level of T-AOC was higher and MDA was lower in non -early stage DN group than early stage DN group （all P〈0.01）. Conclusion The capability of anti-oxidation is weakened in T2DM, and more seriously in T2DM with early stage DN and MS. The results imply that the anti-oxidation therapy may be effective for the high level oxidative stress.

关 键 词：糖尿病 2型 糖尿病肾病 氧化性应激 代谢综合征 

分 类 号：R587.1[医药卫生—内分泌]