慢性乙型肝炎患者血清转化生长因子β_1、肝细胞生长因子的检测及临床意义  

Serum levels of transforming growth factor-β_1 and hepatocyte growth factor in chronic hepatitis B patients

作　　者：宋新文[1] 邓存良[2] 盛云建[2] 

机构地区：[1]新乡医学院第一附属医院感染疾病科 [2]泸州医学院附属医院感染科,四川泸州646000

出　　处：《临床荟萃》2007年第14期1001-1003,共3页Clinical Focus

基　　金：四川省科委科研基金资助(01SY051-29);四川省卫生厅科研基金资助(000112)

摘　　要：目的探讨慢性乙型肝炎病理过程中血清转化生长因子β1(TGF-β1)、肝细胞生长因子(HGF)水平的变化及其临床意义。方法48例慢性乙型肝炎患者和20例健康人均于清晨空腹采血以双抗体夹心酶联免疫吸附测定法检测血清TGF-β1、HGF水平并同时检测肝功能和乙型肝炎病毒脱氧核糖核酸(HBV DNA)水平。结果慢性乙型肝炎患者轻度组、中度组、重度组血清TGF-β1、HGF水平均显著高于对照组,TGF-β1分别为(167.5±87.6)μg/L、(313.1±96.3)μg/L(、495.9±134.4)μg/L vs(81.4±40.7)μg/L,MGT分别为(1530.4±912.2)ng/L(、2461.5±1624.7)ng/L、(3805.2±2104.8)ng/L vs(270.3±123.5)ng/L(均P<0.05),且与丙氨酸转氨酶(ALT)、总胆红素(TBil)水平呈正相关(r=0.625,r=0.568,r=0.579,r=0.612);HBV DNA阳性组和阴性组血清TGF-β1、HGF水平比较差异无统计学意义。结论细胞因子TGF-β1、HGF参与了慢性乙型肝炎的病理生理过程,其水平变化与肝脏损伤程度密切相关。Objective To investigate serum levels of transforming growth factor-β1 （TGF-β1） and hepatocyte growth factor（HGF） in chronic hepatitis B（CHB）. Methods Serum TGF-β1, HGF, HBV DNA and liver function of 48 CHB patients were measured by specific-enzyme linked immunoadsorbent assay, and 20 healthy persons served as the control group. Results TGF-β1 level in light CHB group, medium and severe CHB group was （167.5±87.6） μg/ L, （313.1±96.3） μg/L, （495.9±134.4） μg/L, which was significantly higher than that of control group （81.4±40.7） μg/L （all P %0.01）. HGF level in light CHB group, medium and severe CHB group was （1 530.4±912.2） ng/L, （2 461.5±1 624.7） ng/L, （3 805.2±2 104.8） ng/L, which was significantly higher than that of control group （270.3±123.5） ng/L （all P %0.01）. Serum levels of TGF-β1 and HGF were positively correlated with those of alanine aminotransferase and total bilirubin （ r =0. 625, r =0. 568, r 0. 579, r =0. 612, respectively）. Serum levels of TGF-β1 and HGF showed no significant difference between HBV DNA patients′positive and negative groups. Conclusion TGF-β1 and HGF may play an important role in liver impairment of the patients with CHB.

关 键 词：肝炎 乙型 慢性 转化生长因子Β 肝细胞生长因子 

分 类 号：R512.62[医药卫生—内科学]