2型糖尿病胰岛素抵抗与冠心病相关性的研究  

Study on the risk factors of cardiovascular diseases in type 2 diabetics

作　　者：倪长林[1] 王伟[1] 

机构地区：[1]天津医科大学代谢病医院心脏科,天津300070

出　　处：《天津医科大学学报》2007年第2期226-228,共3页Journal of Tianjin Medical University

摘　　要：目的:探讨2型糖尿病(T2DM)患者胰岛素抵抗和发生冠心病(CHD)的相关性。方法:将已确诊为T2DM的96例患者,根据其是否并发CHD分为两组,其中单纯T2DM组51例,T2DM并发CHD组45例。了解并检测两组患者性别、年龄、体重、病程、体重指数(BMI)、收缩压(SBP)、舒张压(DBP)、血糖(FBG、P2BG)、胰岛素(FINS、PINS)、糖化血红蛋白(HbA1C)、胆固醇(TC、HDL-C、LDL-C、VLDL-C)、甘油三酯(TG)、血尿酸(UA)、胰岛素抵抗指数(HOMA-IR)和24h微量白蛋白排泄率(UAE)、纤维蛋白原(FIB)、C-反应蛋白(S-CRP),行统计学处理。结果:(1)两组在HbA1C、FBG、TG、TC、HDL-C、FINS、UMA,PINS、FIB、S-CRPSBP、DBP、UA、方面差异无统计学意义(P>0.05)。(2)两组在病程、BMI、P2BG、LDL-C、HOMA-IR、P2BG/FBG有统计学差异(P<0.05)。结论:T2DM患者的胰岛素抵抗指数BMI、P2BG、波动性高血糖等与冠心病发生成明显相关性。Objective： To explore the risk factors of cardiovascular diseases in type 2 diabetics. Methods： 96 Patients with type 2 diabetes mellitus （T2DM）, were divided into two groups, 45 in group one with coronary heart disease （CHD）, 51 in group two without CHD. In these two groups, their gender, age, weight, duration and smoking or not, BMI, SBP, DBP, FBG, P2BG, FINS, PINS, GHbA1C,HDL-C, LDL-C, VLDL-C, TG were determined. Results： （1） There is no difference about DBP, GHbA1c, FBG, TG, TC, HDL-C, VLDL-C, PINS, FIB, S-CRP ,SBP, DBP,UA, （P〉0.05）. （2）In the group of DM with CHD, the factors of duration, BMI, P2BG, LDL- C, FINS, HOMA-IR, UMA, P2BG/FBG, peripheral artery occlusion were higher than those in the other group （P〈0.05）. Conclusion： The risk factors to CHD in T2DM include： duration, BMI, P2BG, HOMA-IR, P2BG/FBG.

关 键 词：2型糖尿病 胰岛素抵抗 冠心病 危险因素 

分 类 号：R587.1[医药卫生—内分泌] R587.2[医药卫生—内科学]