肾疏宁对肾小管间质损害大鼠FN、ColⅢ、PAI-1 mRNA的作用  

The Effect of Herbal Medicine of Shenshuning(SSN) on FN、ColⅢ、PAI-1 mRNA Expression in Tubulointerstitial Injury Rats

作　　者：李国霞[1] 黄文政[2] 朱小棣[2] 

机构地区：[1]天津医科大学中西医结合国际学院,天津300070 [2]天津中医药大学第一附属医院,天津300193

出　　处：《中国中西医结合肾病杂志》2007年第7期388-390,共3页Chinese Journal of Integrated Traditional and Western Nephrology

摘　　要：目的：观察肾疏宁对肾小管间质损害大鼠FN、colm、PAl—lmRNA表达的影响。方法：在系膜增生性肾炎（MsPGN）模型基础上。延长造模时间至12～16周，使其自然发展成肾小管间质损害模型，观察肾疏宁对肾小管间质FN、colm、PAl—lmRNA表达的影响，并设苯那普利为阳性对照组。结果：第12～16周末，造模各组肾小管间质FN、ColⅢ、PAI-1mRNA表达量均明显升高（P〈0．05或P〈0．01），肾疏宁组、苯那普利组均显著低于模型组（P〈0．05或P〈0．01），第12周末，肾疏宁组与苯那普利组比较无统计学差异（P〉0．05），而第16周末，肾疏宁组明显低于苯那普利组（P〈0．01）。结论：肾疏宁能抑制细胞外基质的合成，促进其降解，从而保护肾小管间质损害。Objective：To study the effect of Shenshuning（SSN） on fibronectin （FN）,collagen type Ⅲ （ColⅢ） and plasminogen activator inhibitor- 1 （PAl - 1 ） mRNA expression in the animal model of progressive tubulointerstitial injury （TII）. Methods：A rat mesangial proliferative glomerulonephritis （MsPGN） model was established, which develops tubulointerstitial lesion at 12-16 weeks. Rats with tubulointerstitial lesions were treated with Shenshuning（SSN）, and benazepril was used as positive control. The expression of the FN, Col m and PAl- l mRNA in the tubulointerstitium was examined. Resets： The expression of the FN, COl m and PAl - 1 mRNA in the tubulointerstitium of untreated group significant increased （ P〈 0.05 or P〈 0.01 ） ; SSN and benazepril significantly decreased the expression of the FN, COl m and PAl - 1 mRNA（ P 〈 0.05 or P 〈 0.01 ） compared to the untreated controls during 12^th- 16^th weeks. The curative effects of SSN was not significantly different from benazepril at 12^th week（ P 〉 0.05 ）, but SSN exhibited a distinct advantage over benazepril at 16^th week （P〈 0.01 ）. Concision： SSN can inhibit formation of extracellular matrix and promote degradation of extracellular matrix, and protect from tubulointerstitial lesions.

关 键 词：肾小管间质损害 肾疏宁 纤维连接蛋白 Ⅲ型胶原 纤溶酶原激活物抑制剂1 

分 类 号：R285.5[医药卫生—中药学]