魏氏梭菌病诊断方法研究进展  

Progress on Diagnostic Methods of Clostridieum welchii Disease

作　　者：李云霄[1] 金鑫[1] 张营[1] 单雪梅[1] 于丹[1] 

机构地区：[1]延边大学农学院,吉林龙井133400

出　　处：《动物医学进展》2007年第7期88-93,共6页Progress In Veterinary Medicine

摘　　要：魏氏梭菌病是由魏氏梭菌引起的,可感染多种动物,以导致犊牛肠毒血症、绵羊羔痢疾、仔猪坏死性肠炎以及兔肠炎等为主要特征的一种重要的人兽共患传染病。该菌通常感染2月龄~10月龄且膘情较好的牛、羊,在其消化道产生大量原毒素,经胰蛋白酶激活变为毒素,从而进入血液,引发的疾病发生非常突然,与家畜“猝死症”有密切联系。病理变化以全身实质器官出血为突出特征,反刍动物以瓣胃、肠管最为明显。目前,已成功研制出浓缩氢氧化铝灭活苗、类毒素疫苗来控制此病。文章综述了近年来针对魏氏梭菌分型,病原、毒素及抗毒素的免疫学和分子生物学等方面诊断技术研究进展。Clostridieum welchii disease is a kind of important infectious diseases that many kinds of animals can be infected, featured of calf enterotoxaemia, sheep dysentery, piglet necroticans enteritis, rabbit enteritis and so on. The germ usually infects strong and fat cows or sheep at 2~10 months, when infected, a great deal of protoxin is produced at the alimentary tract and then activated to change into toxin by trypsinase, absorbed into blood, causing sudden onset of the disease. It is related with the cattle sudden death. The profluvium sanguinis of parenchymal organs all over the body is the capital pathological change, which can be found predominantly in the omasum and intestinal canal of ruminate animal. Currently, inactivated vaccine and toxoid vaccine has been developed to control the disease. This paper mainly reviewed the progress in serotype of the pathogen and in immunological and molecular biological diagnosis on the toxin and antitoxin.

关 键 词：魏氏梭菌病 魏氏梭菌毒素 魏氏梭菌分型 诊断技术 

分 类 号：S852.617[农业科学—基础兽医学]