三康胶囊对环磷酰胺所致免疫功能低下小鼠的保护作用  

Protective Effect of Sankang Capsule on Immunity-deficiency Mice Induced by Cyclophosphamide

作　　者：张旭[1] 张汝学[2] 涂宏海[3] 贾正平[2] 李茂星[2] 王娟[2] 

机构地区：[1]兰州大学药学院,甘肃兰州730000 [2]兰州军区兰州总医院全军临床药理基地,甘肃兰州730050 [3]新疆军区药品仪器检验所,新疆乌鲁木齐830063

出　　处：《中药材》2007年第6期690-693,共4页Journal of Chinese Medicinal Materials

基　　金：全军医科学技术研究"十一五"计划重大专项课题项目(No.06D005-5)

摘　　要：目的:观察三康胶囊对环磷酰胺所致免疫低下小鼠免疫功能的影响。方法:用环磷酰胺(100 mg/kg,ip)制备小鼠免疫低下模型,灌胃给予不同剂量的三康胶囊(250 mg/kg,500 mg/kg)和阳性对照药贞芪扶正胶囊(500mg/kg),观察小鼠外周血白细胞计数、免疫器官重量、单核吞噬细胞吞噬指数、血清溶血素水平和脾脏淋巴细胞转化指数。结果:对免疫功能低下小鼠,三康胶囊能增加外周血白细胞数量及免疫器官指数,增强单核吞噬细胞的吞噬能力,提高血清溶血素水平和脾脏淋巴细胞转化指数。结论:三康胶囊能够增强环磷酰胺所致免疫功能低下小鼠非特异性免疫和特异性免疫功能,对免疫失衡机体具有保护作用。Objective： To study the immunomodulatory effect of Sankang Capsule（SKC） on the immunity-deficiency mice. Methods ： The immunity-deficiency model was induced by intraperitoneal injection （ip） of cyclophosphamide（CTX） at the dose of 100 mg/ kg in mice which were randomly divided into normal control group, immunity-deficiency model group, SKC treated group （250 mg/kg, 500 mg/kg） and positive control group （500 mg/kg）. The number of WBC in peripheral blood, the weight of immune organs, the phagocytosis activity of macrophage, the content of serum hemolysin and the proliferation of T lymphocyte in the spleen were measured. Results ： The number of WBC, the weight of immune organs, the phagocytosis activity of macrophage, the content of serum hemolysin and the proliferation of T lymphocyte in the model group were all decreased compared with those of normal control group. After the ad- ministration of SKC, the index mentioned above was increased compared with those of model group. Conclusion： SKC has a protective effect on the immunity-deficiency mice, which may be related to the increasing of cellular immunity, humoral immunity and nonspecific immunity.

关 键 词：三康胶囊 免疫低下 小鼠 

分 类 号：R285.5[医药卫生—中药学]