慢性乙肝和肝硬化患者血清一氧化氮水平变化的临床意义  

Clinical Significance of Serum Nitric Oxide Change in Patients with Chronic Hepatitis B and Liver Cirrhosis

作　　者：曲正 杨耀娴[2] 曲伟[3] 王颖慧[3] 

机构地区：[1]上海中冶医院内科,上海200941 [2]包头医学院第二附属医院 [3]包头医学院第一附属医院

出　　处：《包头医学院学报》2007年第3期251-253,共3页Journal of Baotou Medical College

摘　　要：目的:探讨慢性乙肝、肝硬化患者血清一氧化氮(NO)水平变化的临床意义。方法:采用硝酸还原酶法检测60例慢性乙肝患者、20例肝硬化患者、30例健康献血者血清NO水平。结果:血清NO水平,慢性乙肝组高于正常对照组(P<0.001),肝硬化组高于慢性乙肝组(P<0.001)。慢性乙肝组、肝硬化组随着病变加重血清NO水平逐渐升高,肝硬化Ch ild-pugh分级B级高于A级(P<0.05),C级高于B级(P<0.01),随着肝硬化病变的加重血清NO水平逐渐升高。结论:肝病血清NO水平可作为判断肝功能损害及肝硬化程度的血清学指标之一,也可作为慢性乙肝、肝硬化疗效评判的观察指标,同时血清NO水平的研究可能为肝病的治疗提供一条新的途径及理论基础。Objective：To study the clinical significance of the serum nitric oxide（NO） level changes in patients with chronic hepatitis B and liver cirrhosis. Methods：The serum NO level was detected in 60 patients with chronic hepatitis B ,20 patients with liver cirrhosis and 30 healthy donors by nitrate reductase method. Results ： The patients with chronic hepatitis B showed higher serum NO level than healthy control group （ P 〈0.001 ）, The serum NO level was higher in patients with liver cirrhosis than that in patients with chronic hepatitis B（ P 〈 0. 001 ）. The higher Child -pugh, the higher serum NO level. The serum NO level was higher in the B group of the Child - pugh than that in the A group（ P 〈0.05）. The serum NO level was higher in the C group of the Child- pugh than that in the B group（ P 〈 0.01 ）. Conlusions：The serum NO level in the patients with disease could reflect the damage to liver function and the severe degree of liver cirrhosis. The serum NO level may also act as one of indictators to evaluate therapeutic efficacy of liver disease treatment. We could find a new way and theoretical basis for treating liver disease through the study of NO.

关 键 词：一氧化氮 慢性乙肝 肝硬化 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学]