苯妥英钠、苯巴比妥的血药浓度及抗癫痫治疗中毒副反应的观察  

Studies of Diphentoin and Phenobarbital Concentration and Drug Adverse Reaction in Antiepileptic Therapy

作　　者：周为[1] 和喜梅[1] 刘学武[1] 

机构地区：[1]河南医科大学医学实验中心

出　　处：《河南医学研究》1997年第2期112-114,共3页Henan Medical Research

摘　　要：目的：观察抗癫痫药苯妥英钠、苯巴比妥的血药浓度与毒副反应发生率的关系。方法：采用高效液相色谱法同时测定抗癫痫药苯妥英钠（ＤＰＨ）和苯巴比妥（ＰＢ）血清药浓度。结果：血药浓度与毒性反应密切相关。ＤＰＨ、ＰＢ在发挥作用时出现不同程度的毒副反应，随浓度增加，发生人次上升，血药浓度ＤＰＨ＞２５ｍｇ／Ｌ，ＰＢ＞５０ｍｇ／Ｌ时，毒副反应明显增加。结论：ＤＰＨ、ＰＢ的最适血药浓度分别为１０～２０ｍｇ／Ｌ及１０～４０ｍｇ／Ｌ。Objective: The aim was to observe the relationship between diphentoin and phenobarbital concentrations and drug adverse reactions. Methods: HPLC was used for simultaneous determination of diphentoin and phenobarbital in serum. Results: The drug adverse reactions were correlated with DPH and PB serum concentrations, there were different toxic symptoms when DPH and PB levels were in therapeutic range, when DPH serum concentration was higher than 25 mg/L, PB serum concentration was higher than 50 mg/L, the drug adverse reactions was significant increased in our test patients. Conclusion: The propriate DPH and PB concentrations were 10～20 mg/L and 10～40 mg/L respectively.

关 键 词：抗癫痫药 苯妥英 苯巴比妥 毒副反应 

分 类 号：R971.6[医药卫生—药品]