DNA甲基化异常与人类肿瘤  

Relationship between DNA methylation aberration and human tumor

作　　者：杨红丹[1] 高世勇[1] 

机构地区：[1]哈尔滨商业大学生命科学与环境科学研究发展中心药物研究所,哈尔滨150076

出　　处：《哈尔滨商业大学学报（自然科学版）》2007年第4期393-399,共7页Journal of Harbin University of Commerce：Natural Sciences Edition

基　　金：国家自然科学基金项目(30400352);教育部重点项目(205045);黑龙江省自然科学基金(D200611);黑龙江省研究生创新基金(YJSCX2006-0077HSD)

摘　　要：DNA甲基化是表遗传学上研究最深入的一种机制,是一种酶介导的化学修饰过程,在DNA的某些碱基上增加一个甲基.在人类的肿瘤中都可以发现不同程度的DNA异常甲基化现象.介绍DNA甲基化在基因表达中的作用及其抑制基因转录、表达的机理,尤其发生在抑癌基因CpG岛和其他相关基因的甲基化异常与肿瘤发生、演进的关系,甲基化的检测方法以及去甲基化在肿瘤治疗方面的应用前景.DNA methylation which is an enzyme- mediated chemical modification that adds a methyl （CH3） group at selecetd sites on DNA is the best understood mechanism in epigenetics. There are different degrees of DNA methylation aberration in human tumor cells. The role of DNA methylation in gene expression and its mechanism of inhibiting gene transcription and expression, especially CpG island of suppress gene and the relationship between methylation aberration of other related genes and the occurrence, advancement of tumor are introduced in this article. Meanwhile examination methods of methylation and the application prospect of demethylation in treating tumor are also mentioned in this article.

关 键 词：DNA甲基化 肿瘤 CPG岛 甲基化检测方法 相关基因 

分 类 号：R965[医药卫生—药理学]