2型糖尿病合并脑梗塞患者的MTHFR基因、eNOS基因多态性位点的联合研究  

MTHFR、eNOS gene polymorphism's connecting research of the patients with T2DM complicating cerebral infarction

作　　者：张春雨[1] 李珍珍[2] 刘罡[1] 呼日勒[1] 

机构地区：[1]内蒙古医学院第一附属医院神经科,呼和浩特010050 [2]内蒙古医学院第一附属医院内分泌科,呼和浩特010050

出　　处：《临床内科杂志》2007年第7期458-460,共3页Journal of Clinical Internal Medicine

摘　　要：目的探讨N5,10-亚甲基四氢叶酸还原酶(MTHFR)基因C677T位点、内皮型一氧化氮合酶(eNOS)基因G894T位点与2型糖尿病合并脑梗塞的关系。方法采用Sequenom系统检测内蒙古地区汉族健康对照组65人、2型糖尿病患者34例、2型糖尿病合并脑梗塞患者42例的MTHFR、eNOS基因型。结果(1)eNOS基因G894T位点2型糖尿病合并脑梗组TT基因型频率、T等位基因频率与对照组比较差异有显著性(P<0.01,P<0.01);2型糖尿病合并脑梗组T等位基因频率与糖尿病组比较差异有显著性(P<0.05),(2)MTHFR基因C677T位点的TT基因型与eNOS基因G894T位点的TT基因型在2型糖尿病人群患脑梗塞方面具有协同作用(P<0.05)。结论MTHFR基因C677T位点和eNOS基因G894T位点变异增加糖尿病患者发生脑梗的危险性,可能是糖尿病患者发生脑梗塞的遗传易感基因。To investigate the association between C667T point mutation of NS, 10-methylene tetrahydrofolate reductase（MTHFR） gene, G894T point mutation of endodermis nitricoxide synthase（eNOS） gene and the patients with type 2 diabetes mellitus （T2DM）complicating cerebral infarction （CI）. Methods Sequenom system was used to test Han nation peoples MTHFR,eNOS genotype of 65 control groups. 34 patients withT2DM and 42 patients withT2DM complicating CI in inner Mongolia. Results （1）eNOS gene G894T sites frequencies of TT homogenesis and T allele in patients with T2DM complicating CI are significently higher than those in control, there is significent difference （P 〈 0.01, P 〈 0.01 ） ;the frequencies of T allele in patients with T2DM complicating CI there is significent difference compare with T2DM （P 〈 0.05）. （2）TYgenotype of eNOS gene G894T site and MTHFR gene C677Tsite have synergistic effect in the patients with T2DM complicating CI（ P 〈 0.05 ）. Conclusion MTHFR gene C677T and eNOS gene G894T site mutation increase chanciness of T2DM proceeding CI,they may be Hered predisposing genes.

关 键 词：N5 10.亚甲基四氢叶酸还原酶 内皮型一氧化氮合酶 脑梗塞 2型糖尿 病 基因多态性 

分 类 号：R587.1[医药卫生—内分泌]