慢性阻塞性肺疾病动态血氧饱和度和睡眠结构改变的研究  

Study on the change of dynamic blood oxygen saturation and sleep architecture for patients with chronic obstructive pulmonary diseases

作　　者：刘剑梅[1] 苏红[1] 龙淑珍[1] 黎雨[1] 

机构地区：[1]广西医科大学第一附属医院呼吸内科,南宁市530021

出　　处：《广西医学》2007年第6期799-800,共2页Guangxi Medical Journal

基　　金：增进人类健康(PSBH)科研课题(PSBH200501)

摘　　要：目的了解慢性阻塞性肺疾病(COPD)患者的血氧饱和度、睡眠结构的变化及其影响因素,为临床COPD的吸氧或无创通气治疗提供理论依据。方法选取中、重度COPD患者、阻塞性睡眠呼吸暂停综合征(OSAS)患者及体检健康者各30例,检测其血氧饱和度及睡眠结构。结果COPD患者夜间血氧饱和度较白天降低(P<0.05);与对照组相比,COPD及OSAS患者Ⅲ+Ⅳ期睡眠减少,快动眼睡眠期减少,觉醒次数增多,差异有统计学意义(P=0.000)。结论COPD患者血氧饱和度处于持续低水平状态,夜间睡眠结构改变与OSAS患者相似,COPD患者应持续的低流量吸氧或使用无创呼吸机治疗。Objective To investigate the change of dynamic blood oxygen saturation and sleep architeetur for patients with chronic obstructive pulmonary diseases（COPD）. Methods The blood oxygen saturation and sleep architecture of 30 moderate or severe COPD patients ,30 obstructive sleep apnea syndrome （ OSAS ） patients and 30 controls were measured by polysomnography. Results The blood oxygen saturation in patients with COPD was lower at night than in the daytime（ P 〈0.05 ）. Compared with controls, Ⅲ ＋Ⅳ stage sleep and REM sleep of COPD group and OSAS group had decreaseof,times of WASO （ wake after sleep onset） but increased. Conclusion The blood oxygen saturation of patients with COPD is low persistently. Their sleep architecture change is similar to that of patients with OSAS. The patients with COPD should uadertake persistent low flow oxygen therapy or noninvasive ventilation treatment.

关 键 词：慢性阻塞性肺疾病 阻塞性睡眠呼吸暂停综合征 血氧饱和度 睡眠结构 

分 类 号：R563[医药卫生—呼吸系统]