新疆亚临床型克汀病流行病学调查报告  

Epidemiological Investigation on Subclinical Cretinism in Xinjiang

作　　者：林法福[1] 赵洪新[1] 马丽亚 王锋锐[1] 杨成忠[1] 马丽[1] 依麻木 蒋继勇[1] 

机构地区：[1]新疆地方病防治研究所,乌鲁木齐市830002

出　　处：《地方病通报》1997年第2期50-56,共7页Endemic Diseases Bulletin

基　　金：卫生部科研基金

摘　　要：按照新疆IDD流行与环境地理特征，沿山前丘陵河谷至河流下游冲积平原（非病区或轻病区），对南疆喀什、巴州及北疆达板城等六个地区约3278名7～14岁学龄儿童进行了全面系统的亚临床克汀病流调及临床检查。结果显示：南疆地区亚克汀病流行强度为14.5％、北疆地区为5.2％，全疆平均为9．14％。据此推测全疆有亚临床克汀病人42．36万人。阐述了新疆亚克汀病与地方性甲状腺肿的地理发病机制，并将病区与非病区相比较，对精神运动障碍、甲状腺摄I131功能，TRH兴奋试验、TSH、T4、FT4、FT3进行了综合临床流行病学分析，分析结果：精神运动测验、TRH兴奋试验、FT4是诊断亚临床克汀病更为敏感和特异的指标。According to the characteristic of epidemic of IDD in Xinjiangand geographical environment, along with piedmont hill valley to wash plain in area of lower reaches of rivers (non-endemic or milid-endemic areas),epidemiological investigation and clinical examination on subclinical cretinism were generally and systematically made in around 3 278schoolchildren at age of 7~ l4 in southern Xinjiang such as Kash, Bayngolin, etc. and northern Xinjiang, for example, Dabancheng, etc.,totally six areas. Results showed that epidemic intensities of subclinical cretinism were 14. 5 % in southern Xinjiang, and 5. 2% in northern Xinjiangrespectively, meanly 9. 14% in Xinjiang. It could be inferred from abovemention that there were 42. 36% hundred thousand patients with subclinical cretinism in Xinjiang. In this paper, geographical pathogeny of subclinical cretinism and endemic goiter was elaborated, and comparedthe endemic area with non-endemic area,psychomotor retardation, I131 absorbing function of thyroid, TRH stimulation test, TSH, F4, FT4,FT3, were also analysed by clinical epidemiology comprehensively. Analysis results were that the psychomotion test,TRH stimulation test and FT4 were much more sensitive and specific indices for diagnosing subclinical cretinism .

关 键 词：克汀病 流行病学 新疆 

分 类 号：R581.210.1[医药卫生—内分泌]