可逆性脑后部白质病变综合征的临床和MRI表现  

Clinical and MRI Features of Reversible Posterior Leukoencephalopathy Syndrome

作　　者：石铸[1] 潘速跃[1] 刘方颖[1] 王群[1] 罗一峰[1] 

机构地区：[1]南方医科大学南方医院神经内科,广州510515

出　　处：《中国医学影像学杂志》2007年第4期292-295,共4页Chinese Journal of Medical Imaging

基　　金：国家自然科学基金项目(30400147);中国博士后科学基金项目(2004036508)

摘　　要：目的:探讨可逆性脑后部白质病变综合征的临床和MRI特点。材料和方法:回顾性分析2例可逆性脑后部白质病变综合征患者的临床和MRI资料。结果:2例中,1例严重的肾病综合征,1例造血干细胞移植后使用免疫抑制药物,均急性起病,以头痛、癫痫发作为首发症状。头颅MRI检查均显示以大脑半球顶枕部白质为主的片状对称性长T1长T2信号、FLAIR高信号病变,额叶也有相同性质的小片状病灶受累。4周后临床症状基本消失,复查头颅MRI原有病灶明显减小或消失。结论:可逆性脑后部白质病变综合征是一种预后良好的疾病,结合病史和MRI特征可以早期诊断。Purpose： To investigate the clinical and MRI characteristics of the reversible posterior leukoencephalopathy syndrome （RPLS）. Materials and Methods： The clinical and MRI features of 2 patients with RPLS were analyzed retrospectively. Results： Of the two patients, one had the history of severe kidney disease syndrome, and the other just received immunosuppressive agents after the bone marrow transplantation for leukemia. Both manifested as acute onset of seizure or severe headache. MRI revealed symmetrical multiple patchy -like lesions presented hypointense on T1WI, hyperintense on T2WI, and located predominantly in the occipital lobe. These lesions disappeared or dwindled when the clinical symptoms resolved 4 weeks later. Conclusion： RPLS usually shows well outcome in prognosis and can be diagnosed on the basis of clinical and MRI features in the early stage.

关 键 词：临床 MRI 可逆性脑后部白质病变综合征 

分 类 号：R692[医药卫生—泌尿科学]