多囊卵巢综合征合并高胰岛素血症患者的内分泌特征及治疗探讨  

Endocrinologic profiles and treatment of polycystic ovary syndrome complicated with hyperinsulinemia

作　　者：范林霄[1] 郝敏[2] 

机构地区：[1]山西省人民医院妇产科,太原030012 [2]山西医科大学第二医院妇产科

出　　处：《中国药物与临床》2007年第7期511-513,共3页Chinese Remedies & Clinics

基　　金：山西省自然科学基金资助项目(20021116)

摘　　要：目的研究多囊卵巢综合征(PCOS)合并高胰岛素血症(HI)患者的内分泌特征,探讨盐酸二甲双胍治疗的机制及效果。方法测定21例HI和15例非HI的PCOS患者血清瘦素(Leptin)、胰岛素样生长因子1(IGF-1)、IGF结合蛋白1(IGFBP-1)、空腹胰岛素(FINS)、黄体生成素(LH)及睾酮(T)水平,并进行比较。PCOS合并HI者应用盐酸二甲双胍500mg,3次/d,治疗8周,比较治疗前后各指标的变化。结果HI组血清Leptin、FINS水平高于非HI组,血清IGFBP-1低于非HI组。盐酸二甲双胍治疗HI组后,血清Leptin、FINS及T水平降低,血清IGFBP-1增高。结论PCOS是否合并HI其内分泌特征不同,盐酸二甲双胍可以改善PCOS合并HI者的内分泌紊乱。Objective To look at the endocrinologic profiles of polycystic ovary syndrome （PCOS） complicated with hyperinsulinemia （HI） and investigate the mechanism underlying the clinical effects of metformin. Methods Serum concentrations of leptin, insulin-like growth factor-1 （IGF-1）, insulin-like growth factor biding protein-1 （IGFBP-1）, fasting ipsulin, luteinizing hormone and testerone were evaluated and compared in 21 PCOS patients with HI and 15 PCOS patients without HI. Patieuts who had both PCOS and HI were, treated with mefformin at a dose of 500 mg three times daily for 8 weeks. Changes in serum levels of the parameters from baseline were recorded. Results Significantly, higher serum levels of leptin and insulin, and lower serum level of IGFBP-1 were observed in the HI group as compared with the non-HI group. Metformin led to significant decrease in serum leptin, insulin and testerone levels, as well as a significant increase in serum IGFBP-I. Conclusion Endocrinologic profiles in PCOS with HI were different from those in non-H1 PCO5. Metformin may improve endocrinologic disorders seen in PCOS with HI.

关 键 词：多囊卵巢综合征 高胰岛素血症 胰岛素样生长因子-1 瘦素 胰岛素样生长因子结合蛋白-1 盐酸二甲双胍 

分 类 号：R711.75[医药卫生—妇产科学] R587[医药卫生—临床医学]