BFS介入治疗MDR—PTB的临床研究  

BFS Intervention Therapy for MDR-PTB

作　　者：崔爱东[1] 周千祥 陈连清[1] 袁晓荣 

机构地区：[1]包头市第三医院呼吸科,内蒙古包头014040

出　　处：《内蒙古医学杂志》2007年第6期667-670,共4页Inner Mongolia Medical Journal

摘　　要：目的:探讨BFS介入治疗MDR—PTB的疗效与安全性。方法:把67例耐多药肺结核病患者随机分成两组:实验组和对照组,实验组经纤维支气管镜病灶灌注高浓度大剂量的药物(异烟肼0.2,丁胺卡那霉素0.2,对氨基水杨酸钠1.0,再加0.9%氯化钠10ml)并合用全身化疗,对照组仅用全身化疗。结果:通过对每个月与满6个月相关指标的统计,与对照组比较,实验组痰菌阴转率、病灶吸收率、空洞闭合率均明显高于对照组,相应的P值分别为(P<0.05,P<0.05,P<0.01)。结论:经纤维支气管镜给药配合全身化疗治疗耐多药肺结核病,疗效显著,优于单纯全身化疗,而且未见严重的并发症和毒副反应。Objective： To investigate the efficacy and safety of BFS intervention therapy for MDR- PTB. Methods：67 cases of drug resistant pulmonary tuberculosis were randomly divided into two groups： experiment group and control group. The experiment group was administrated with massive dose of drugs including isonlazid 0.2, amikacin 0.2, para - anionosalicylic and Sodium Chloride in dose of 10ml through bronchofibroscope combined with general chemotherapy. The controls received general chemotherapy. Results： Compared with control group, the rate of negative sputum bacteria, the rate of absorbed lesion and the rate of closed calvity increased at every month and the sixth months（ P 〈 0.05, P 〈 0.05, P 〈 0.01 ）. Conclusion： The medication by bronchofibroscope combined with general chemotherapy were effective in treatment of drug resistant pulmonary tubeeulosis, its effect is superior to general therapy. There are no serious complications and toxic and adverse reaction occurred

关 键 词：耐多药肺结核 纤维支气管镜 介入治疗 

分 类 号：R459.3[医药卫生—治疗学] R520.53[医药卫生—临床医学]