乌灵胶囊治疗卒中后抑郁的疗效观察  

Observation on Effect of Wuling Capsule in Treating Poststroke Depression

作　　者：徐彬[1] 周未莹[1] 章水晶[1] 

机构地区：[1]浙江中医药大学附属第二医院,浙江省新华医院神经内科,杭州310005

出　　处：《中国中西医结合杂志》2007年第7期640-642,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察乌灵胶囊治疗卒中后抑郁的疗效。方法108例患者按数字表法随机分为3组,每组36例,3组均接受常规药物治疗,联合组用乌灵胶囊和百优解,百优解组和乌灵组分别单用百优解和乌灵胶囊;于治疗前和治疗后4、12周,采用汉密尔顿抑郁量表(HAMD)、简易智能状态量表(MMSE)、神经功能缺损评分量表(SSS,用改良爱丁堡斯堪的那维亚评分)和Barthel指数(BI)进行评定患者的认知和神经功能状况。结果3组HAMD和SSS评分治疗后均较治疗前显著下降(P<0.01);而MMSE和BI指数3组治疗后均较治疗前显著升高(P<0.05),联合组HAMD评分下降和BI指数比另两组增高更为明显(P<0.05)。结论乌灵胶囊对卒中后抑郁有良好的治疗作用,与百优解合用有协同效应。Objective To evaluate the efficacy of Wuling Capsule （WLC） in treating patients with poststroke depression. Methods One hundred and eight patients with poststroke depression were randomly assigned to three groups, 36 in each. All were treated with routine medicine, but to the WLC group and the FLX group, additional WLC and fluoxetine was given respectively, while to the combined group, both of the two were given. Patients＇ neurological and cognitive function were estimated by HAMD scale, MMSE scale, SSS scale and Barthel index （BI） before treatment and at 4 weeks and 12 weeks after treatment, Results HAMD score and SSS score significantly decreased （P 〈 0.01 ） while MMSE score and BI score significantly increased （P 〈 0.05） in all the three groups, but the improvement in decrease of HAMD score and in increase of BI score in the combined group was more significant than those in the other two groups respectively （P 〈 0.05 ）. Conclusion WLC is effective in treating patients with poststroke depression and shows synergism with fluoxetine.

关 键 词：乌灵胶囊 百优解 卒中后抑郁 汉密尔顿抑郁量表 

分 类 号：R277.7[医药卫生—中医学]