巯甲丙脯酸治疗急性下壁心肌梗死的电生理和血液动力学研究  

ELECTROPHYSIOLOGIC AND HAEMODYNAMIC EFFECTS OF CAPTOPRIL IN THE TREATMENT OF ACUTE INFERIOR MYOCARDIAL INFARCTION

作　　者：毛树森[1] 卢才义[1] 黄丛春[1] 魏璇[1] 贾广兴[1] 

机构地区：[1]空军总医院

出　　处：《解放军医学杂志》1997年第2期83-85,共3页Medical Journal of Chinese People's Liberation Army

摘　　要：为了探讨巯甲丙脯酸（ＣＰＴ）增加下壁心肌梗死（ＩＮＦ）并发症和病死率的原因，在实验性心肌梗死模型上观察了ＣＰＴ对ＩＮＦ的电生理和血液动力学作用，并与前壁心肌梗死（ＡＮＴ）进行比较。结果表明：ＣＰＴ明显延长ＩＮＦ的窦房结恢复时间和心房、心室、房室交界区的有效不应期，使心率减慢、房室传导阻滞发生率增加；与ＡＮＴ相比，ＩＮＦ患者使用ＣＰＴ后动脉压下降更为显著，左室舒张末压轻度下降。提示，ＣＰＴ治疗增加ＩＮＦ并发症和病死率的原因可能与ＣＰＴ对ＩＮＦ的负性心电生理和血液动力学效应有关。因此，ＩＮＦ急性期不宜采用ＣＰＴ治疗。The electrophysiologic and haemodynamic effects of captopril were studied on the experimental models of acute inferior myocardial infarction and compared with those on anterior infarction models. The results showed that in inferior infarction, captopril significantly prolonged sinus node recovery time and the effective refractory periods of atrium, ventriculum and atrioventricular junction, slowed the heart rate, increased atrioventricular block rate and decreased arterial blood pressure and left ventricular end diastole pressure. Therefore, it is concluded that (1) the negative electrophysiologic and haemodynamic effects of captopril are related to the increase of complications and case fatality rate of inferior myocardial infarction treated by captopril; (2)captopril is not indicated to treat acute inferior myocardial infarction.

关 键 词：心肌梗塞 药物疗法 巯甲丙脯酸 血液动力学 

分 类 号：R542.220.5[医药卫生—心血管疾病]