宫内发育迟缓儿脐血胰岛素样生长因子1、胰岛素样生长因子结合蛋白3、胰岛素及瘦素的关系  

Relationship between levels of serum insulin-like growth factor 1,insulin-like growth factor-binding protein-3,leptin and insulin levels in intrauterine growth retardation

作　　者：林亚芬[1] 陈兆文[1] 濮泽琼[1] 李伟华[1] 陈碧琴[1] 汤红萍[1] 虞乐萍[2] 张旭霞[2] 钱蓓倩[2] 

机构地区：[1]复旦大学附属金山医院儿科,上海200540 [2]复旦大学附属妇产科医院儿科

出　　处：《上海医学》2007年第6期425-427,共3页Shanghai Medical Journal

基　　金：上海市科委科研基金(034119812)

摘　　要：目的探讨宫内发育迟缓(IUGR)儿出生后脐血胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白3(IGFBP3)、胰岛素(Ins)及瘦素(Lep)的变化。方法选择141例IUGR儿为IUGR组,以同期出生的足月、适于胎龄儿30例作为对照组,比较两组出生后脐血IGF-1、IGFBP3、Ins和Lep的浓度。结果IUGR组IGF-1、IGFBP3、Ins和Lep的浓度均明显低于对照组(P值分别＜0．01、0．05)。IUGR组IGF-1与IGFBP3(r= 0．6434)和Ins(r=0．4367)、Ins与Lep(r=0．3461)均呈正相关(P值均＜0．01),IGF-1与Lep、IGFBP3与Ins和Lep均不相关(P值均＞0．05)。结论IGF-1、IGFBP3、Ins及Lep低下是导致IUGR的原因, Ins-IGF-1-IGFBP3及Ins-Lep轴各自调控胎儿的生长发育。Objective To investigate the change of serum levels of insulin-like growth factor 1 （IGF-I）, insulin-like growth factor-binding protein-3 （IGFBP3）, leptin and insulin levels in intrauterine growth retardation （IUGR）. Methods Levels of serum IGF-I, IGFBP3, Leptin and insulin in the cord blood were measured in 141 IUGR and 30 normal newborns. Results Levels of serum IGF-I, leptin of IUGR were significantly lower than those of normal newborns （P 〈 0.01） ; the levels of IGFBP3, insulin of IUGR were also significantly lower than those of the normal newborns （P 〈 0.05）. Serum. IGF-I was significantly correlated with IGF-BP3 and insulin levels （P 〈 0.05）, but not with [eptin （P 〉 0.05）. IGF-BP3 level was not correlated with Leptin and insulin level （P 〉 0.05）. Insulin had significant relevance with leptin （P 〈 0.05）. Conclusion The low serum levels of insulin, IGF-I, IGFBP3 and leptin can result in development of IUGR. Insulin-IGF-I-IGFBP3 and insulin-leptin controls the growth and development of the fetus. （Shanghai Med J, 2007, 30：425-427）

关 键 词：宫内发育迟缓儿 胰岛素样生长因子-1 胰岛素样生长因子结合蛋白3 胰岛素 瘦素 

分 类 号：R714.5[医药卫生—妇产科学]