上海地区初中生CYP3A酶活性分布  

Distribution of CYP3A activity of students in junior middle school in Shanghai

作　　者：陈敏玲[1] 张顺国[1] 蔡卫民[2] 

机构地区：[1]上海交通大学医学院附属新华医院上海儿童医学中心药剂科,上海200127 [2]上海交通大学医学院附属瑞金医院药剂科,上海200025

出　　处：《中国临床药学杂志》2007年第4期227-230,共4页Chinese Journal of Clinical Pharmacy

摘　　要：目的 了解上海地区初中生CYP3A酶活性的分布.方法 采用HPLC法测定尿液中氢化可的松和6β-羟基氢化可的松的浓度，以6β-羟基氢化可的松/氢化可的松的浓度比来表示CYP3A酶的活性.结果 980名受检者CYP3A酶的活性为5.21±2.32，年龄（X）与CYP3A酶的活性（Y）的线性方程为：Y=0.342 X＋0.900.结论 上海地区初中生CYP3A酶活性无性别差异，其正常值范围为 1.00～27.16.AIM To investigate the distribution of CYP3A activity （CA） of the students at junior middle school in Shanghai. METHODS Urine concentrations of hydrocortisone and 6β-hydroxycortisol. were determined by a HPLC method, The urinary ratio of 6β-hydroxycortisol / hydrocortisone had been used as a noninvasive probe for human CYP3A. RESULTS The mean value of CYP3A activity in 980 measured was 5.21 ＋ 2.32. Between age（X） and CA （Y）, the linear equation was Y = 0. 342 X ＋ 0. 900. CONCLUSION There is no differences of CA in gender. The range of nomud values is 1.00 - 27.16.

关 键 词：CYP3A 氢化可的松 分布 尿液 

分 类 号：R96[医药卫生—药理学]