广西毛南族6个短串联重复序列的遗传多态性  

Genetic polymorphisms of six STR loci in Maonan population in Guangxi province

作　　者：滕少康[1] 徐林[2] 劳明[2] 周丽宁[2] 邓琼英[2] 李松峰[2] 龚继春[2] 

机构地区：[1]广西右江民族医学院人体解剖学教研室,广西百色533000 [2]广西医科大学人体解剖学教研室,广西南宁530021

出　　处：《基础医学与临床》2007年第7期745-748,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(30260044)

摘　　要：目的调查广西毛南族人群6个短串联重复序列的群体遗传分布资料,探讨7个民族的遗传关系。方法应用荧光标记STR基因扫描技术分析200名广西毛南族无关个体。以遗传距离和系统发生树来分析7个民族间的遗传关系。结果6个STR基因座平均观察杂合度0.7825,平均多态信息总量分别为0.7324,累积个体识别力达0.99999951,累积非父排除率达0.994575。鄂伦春族、东乡族、锡伯族3个民族聚为一支,金秀瑶族、融水苗族、罗城仫佬族、毛南族4个少数民族聚成另一支。结论D3S1358的等位基因16、D5S818的等位基因11、D7S820的等位基因11、D13S317的等位基因8、vWA的等位基因14、FGA的等位基因22可能是广西毛南族群体中相应STR基因座最原始的等位基因。广西毛南族的6个STR基因座属高度遗传多态性标记,广西毛南族与罗城仫佬族的遗传关系最近,其次分别为融水苗族、金秀瑶族、锡伯族、东乡族、鄂伦春族。Objective To investigate the distribution of six short tandem repeats （STR） loci in Maonan in Guangxi province and to study genetic relationship among 6 minorities. Methods Two hundreds unrealated individulas were analyed by STR genescanning. Genetic distance was computed and phylogenetic tree was construted for studying genetic relationship among 6 Ethnic groups. Results The average heterozygosity（H） in the six STR loci was 0.7825 ; the average polymorphism information content（ PIC ） was 0. 7324 ; the accumulative discrimination power（DP） was 0. 99999951 ,and the accumulative probability of paternity exclusion （EP） was 0. 994575. All 6 populations were clustered into 2 group. Conclusion Allele 16 in D3S1358, allele 11 in D5S818, allele 11 in D7S820,8 in D13S317,14 in vWA,22 in FGA are probably the most primitive alleles in repective locus. The data obtained indicate highly genetic polymorphisms. Genetic relation between Maonan and Mulao were close.

关 键 词：短串联重复序列 遗传多态性 毛南族 系统发生分析 

分 类 号：Q987[生物学—遗传学]