原发性醛固酮增多症与嗜铬细胞瘤的诊治分析  

Clinical analysis to the primary aldosteronism and pheochromocytoma

作　　者：李志立[1] 刘凡[2] 张伟[3] 杨欣国[1] 赵连友[1] 金葵花[1] 吴学勤[1] 

机构地区：[1]第四军医大学唐都医院心内科,西安710038 [2]第四军医大学唐都医院泌尿外科,西安710038 [3]第四军医大学唐都医院病理科,西安710038

出　　处：《临床心血管病杂志》2007年第7期522-524,共3页Journal of Clinical Cardiology

摘　　要：目的:提高原发性醛固酮增多症(PAS)与嗜铬细胞瘤(PCM)的诊治水平。方法:手术治疗的住院患者76例:PAS组35例,PCM组41例。对患者一般资料、临床表现、血清生物化学及肿块病理性质等进行分析。结果:与PCM组比较,PAS组血清钾离子浓度显著降低(P<0.01),醛固酮浓度显著升高,瘤体较小,CT检出率较低;PCM组尿香草基杏仁酸浓度显著升高。PAS组腺瘤占80.0%,PCM组髓质嗜铬细胞瘤占85.4%。结论:血清钾离子浓度降低是诊断PAS最重要指标,检测尿香草基杏仁酸是诊断PCM的关键,CT和MRI检查可提高对PAS、PCM的诊断率;手术治疗是降低血压确实有效的治疗措施。Objective：To study the diagnosis and treatment to the primary aldosteronism （PAS） and pheochromycytoma （PCM）. Method：There were thirty five patients with PAS and forty-one patients with PCM collected in this study. General status, clinical manifestations, laboratory findings and the pathology of the tumor were analyzed. Result：In group PAS the concentrations of the potassium in serum were lower and the aldosterone were significantly higher, while adrenal tumors were smaller and the positive percentage of the test by CT scans was lower than those in group PCM. The concentrations of the urine metanephrine were significantly increased in group PCM. Adenoma was 80.0% of the tumors in group PAS, and medulla PCM was 85.4% of tumors in group PCM. Conclusion：The decrease concentration of the potassium in serum is important to the diagnosis of PAS, CT and MRI scan are useful to confirm the diagnosis for PAS and PCM. Surgical treatment is the effective method to decrease the blood pressure.

关 键 词：醛固酮增多症 嗜铬细胞瘤 外科手术 

分 类 号：R586.2[医药卫生—内分泌]