4,4-二甲基-1-(4-氯苯基)-3-戊酮的合成  

Synthesis of 1-(4-chloro-phenyl)-4,4-dimethyl-pentan-3-one

作　　者：张谦[1] 谭成侠[1] 何为 陈雪锦 沈德隆[1] 

机构地区：[1]浙江工业大学化学工程与材料学院,浙江杭州310032 [2]浙江新和成股份有限公司,浙江新昌312500

出　　处：《浙江工业大学学报》2007年第4期386-388,共3页Journal of Zhejiang University of Technology

基　　金：浙江省教育厅基金资助项目(20030145)

摘　　要：以对氯苯甲醛和频哪酮为原料,经缩合、氢化合成4,4-二甲基-1-(4-氯苯基)-3-戊酮.工艺选择了强碱性离子交换树脂为碱性催化剂以及采用CO2中和体系中的碱性物质,使4,4-二甲基-1-(4-对氯苯基)-1-戊烯-3-酮的收率达到98.3%,纯度达到97.4%;氢化反应中通过调节反应体系的pH值及使用添加剂如N,N-二甲基甲酰胺可减少副产物脱氯产物的产生,提高了目标产物的含量和收率,分别达到了98.7%,收率达到98%以上.该工艺各项经济技术指标均超过文献水平.Using 4-chlorophenyl aldehyde and 3,3-Dimethyl-2-butanone as raw materials, 1-（4- Chloro-phenyl）-4, 4-dimethyl-pentan-3-one was synthesized by condensation and hydrogenation processes. The yield of 1-（4-Chloro-phenyl）-4,4-dimethyl-pent-1-en-3-one can be reached 98.3 % with the purity of 97.4% （GC） by using strongly basic ion exchange resin and CO2. By regulating value of pH and using flux such as N,N-dimethyl formamide, the dechloridizing byproduct was reduced, and the yield of 1-（4-Chloro-phenyl）-4, 4-dimethyl-pentan-3-one can be reached 98% with the purity 98.7% （GC）. Economic and technical indices of the above synthetic method are more favorable than those previously reported.

关 键 词：戊唑醇 强碱性离子交换树脂 4 4-二甲基-1-(4-氯苯基)-3-戊酮 

分 类 号：O622.4[理学—有机化学]