3-乙磺酰基-2-吡啶磺酰胺的合成  

Synthesis of 2-aminosulfonyl-3-ethylsulfonyl pyridine

作　　者：卢鑫鑫[1] 杨鑫骥[1] 翁建全[1] 沈德隆[1] 陈庆悟[1] 

机构地区：[1]浙江工业大学化学工程与材料学院,浙江杭州310032

出　　处：《浙江工业大学学报》2007年第5期494-496,共3页Journal of Zhejiang University of Technology

摘　　要：3-乙磺酰基-2-吡啶磺酰胺是磺酰脲类除草剂玉嘧磺隆重要中间体.以乙磺酰基乙腈和1,1,3,3-四甲氧基丙烷为起始原料,经消除加成、取代、环合、硫代和磺酰胺化五步反应合成得到目标产物.质量分数为98.5%,总收率46.5%(以乙磺酰基乙腈计).产物及中间体结构经1H NMR和MS表征确认.2-aminosulfonyl-3-ethylsulfonyl pyridine was an important intermediate of rimsulfon. Using 1,1,3,3-tetramethoxypropane and ethylsulfonyl acetonitrile as starting materials, it was synthesized by a five-step reaction, i. e. elimination-addition, displacement reaction, cyclization reaction, sulph reaction, sulfonamination reaction. The total yield was 46. 5% and the content was above 98.5 %. The structures of product and intermediates were comfimed by ^1H NMR and MS.

关 键 词：乙磺酰乙腈 玉嘧磺隆 闭环反应 

分 类 号：O626.321[理学—有机化学]