纤变灵对口腔粘膜下纤维化大鼠ET-1表达的影响  

Effect of DanXuan KouKang on the expression of ET-1 in OSF rats

作　　者：谭劲 陈安 TAN Jin, CHEN An, , CHEN Ming, （The First Affiliated Hospital, TCM Univ. of Hunan Changsha 410007, China）

机构地区：湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《中外健康文摘：医药月刊》2007年第6期54-56,共3页

摘　　要：目的研究纤变灵（XBL）对模型大鼠口腔粘膜下纤维化（OSF）内皮素-1（ET-1）表达的影响。方法将40只大鼠随机分为A（正常对照组）、B（模型对照组）、C（纤变灵组）、D（雷公藤多甙LGTDD组）4组,每组10只,B、C、D组经槟榔提取物（ANE）刺激下制作OSF模型后,B组不作任何处理;C、D组分别以XBL和LGTDD连续灌胃8周。采集口腔颊部粘膜进行ET-1免疫组化检测。结果模型组ET-1的表达明显高于正常对照组（p〈0.01）;药物干预后,纤变灵组ET-1表达明显低于模型组和雷公藤多甙组（P〈0.01）。结论XBL能够降低ET-1在大鼠OSF组织中的表达,这可能是XBL治疗OSF的机理之一。Objective： To study the effect of XianBianLing（XBL） on Endothelin-l（ET-1 ）expression in OSF tissue of rats. Methods： 40 rats were randomly divided into A （normal control）, B （OSF control）, C （XBL）, D （LGTDD） groups. A group was normal control; after stimulated by ANE to creat OSF models , B group was with no intervention, C and D groups were given XBL and LGTDD respectively Via gastrogavage for 8 weeks. The expressions of ET-1 in oral mucous were examined through immunohisto-chemistry method. Results： The expression of ET-1 in group B significantly increased as compared with group A （p〈0.01）; after administration, the expression of ET-1 in group C significantly decreased as compared with group B and group D （p〈0.01）. Conclusions： These results indicate that administration of XBL following OSF significantly reduces expression of ET-1, it might be one of mechanisms of XBL in the treatment of OSF.

关 键 词：纤变灵 口腔粘膜下纤维化 槟榔提取物 内皮素-1 

分 类 号：R284.2[医药卫生—中药学;医药卫生—中医学]